| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RA Capital Management, L.P. | 7.2% | 1,200,000 | 0 | 1,200,000 | /s/ Peter Kolchinsky | By Peter Kolchinsky, Authorized Signatory | |
| Peter Kolchinsky | 7.2% | 1,200,000 | 0 | 1,200,000 | /s/ Peter Kolchinsky | Peter Kolchinsky | |
| Rajeev Shah | 7.2% | 1,200,000 | 0 | 1,200,000 | /s/ Rajeev Shah | Rajeev Shah | |
| RA Capital Healthcare Fund, L.P. | 6.9% | 1,140,000 | 0 | 1,140,000 | /s/ Peter Kolchinsky | By RA Capital Healthcare Fund GP, LLC, its General Partner, By Peter Kolchinsky, Manager |