| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| RTW Investments, LP | 5.9% | 12,368,334 | 0 | 12,368,334 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D., Managing Partner | |
| Roderick Wong, M.D. | 5.9% | 12,368,334 | 0 | 12,368,334 | /s/ Roderick Wong, M.D. | Roderick Wong, M.D. |