| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 7.7% | 3,637,887 | 0 | 3,637,887 | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001055951 |
| ORBIMED CAPITAL GP VII LLC | 6.3% | 2,958,000 | 0 | 2,958,000 | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC | 0001760648 |
| OrbiMed Genesis GP LLC | 1.4% | 679,887 | 0 | 679,887 | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC | 0001808744 |