| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 2.3% | 1,666,800 | 0 | 1,666,800 | /s/ Carl L. Gordon | Carl L. Gordon/Member | |
| OrbiMed Capital LLC | 5% | 3,568,346 | 3,568,346 | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member |