| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 3.1% | 2,174,700 | 0 | 2,174,700 | /s/ Carl L. Gordon | Carl L. Gordon / Member | |
| OrbiMed Capital LLC | 6.6% | 4,655,600 | 4,655,600 | 0 | /s/ Carl L. Gordon | Carl L. Gordon / Member |