| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 8% | 2.61M | 0 | 2.61M | /s/ Carl L. Gordon | Carl L. Gordon / Member | |
| OrbiMed Capital GP VI LLC | 8% | 2.61M | 0 | 2.61M | /s/ Carl L. Gordon | Carl L. Gordon / Member of OrbiMed Advisors LLC |