| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 10.5% | 3.41M | 0 | 3.41M | /s/ Carl L. Gordon | Carl L. Gordon / Member | |
| OrbiMed Capital GP VI LLC | 10.5% | 3.41M | 0 | 3.41M | /s/ Carl L. Gordon | Carl L. Gordon / Member of OrbiMed Advisors LLC |