| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 6.9% | 773,754 | 0 | 773,754 | /s/ Carl L. Gordon | Carl L. Gordon, Member | 0001055951 |
| ORBIMED CAPITAL GP VI LLC | 6.7% | 753,063 | 0 | 753,063 | /s/ Carl L. Gordon | Carl L. Gordon, Member of OrbiMed Advisors LLC | 0001682115 |
| OrbiMed Genesis GP LLC | 0.19% | 20,691 | 0 | 20,691 | /s/ Carl L. Gordon | Carl L. Gordon, Member of OrbiMed Advisors LLC | 0001808744 |
| ORBIMED CAPITAL LLC | 1.2% | 135,516 | 135,516 | 0 | /s/ Carl L. Gordon | Carl L. Gordon, Member | 0001157524 |