| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 17% | 8,008,913 | 0 | 8,008,913 | /s/ Carl L. Gordon | Carl L. Gordon, Member | 0001055951 |
| ORBIMED CAPITAL GP VI LLC | 16% | 7,768,790 | 0 | 7,768,790 | /s/ Carl L. Gordon | Carl L. Gordon, Member of OrbiMed Advisors LLC | 0001682115 |
| OrbiMed Genesis GP LLC | 0.5% | 240,123 | 0 | 240,123 | /s/ Carl L. Gordon | Carl L. Gordon, Member of OrbiMed Advisors LLC | 0001808744 |
| ORBIMED CAPITAL LLC | 3.3% | 1,572,638 | 1,572,638 | 0 | /s/ Carl L. Gordon | Carl L. Gordon, Member | 0001157524 |