| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 16.71% | 8.01M | 0 | 8.01M | /s/ Carl L. Gordon | Carl L. Gordon, Member | 0001055951 |
| ORBIMED CAPITAL GP VI LLC | 16.21% | 7.77M | 0 | 7.77M | /s/ Carl L. Gordon | Carl L. Gordon, Member of OrbiMed Advisors LLC | 0001682115 |
| OrbiMed Genesis GP LLC | 0.5% | 240K | 0 | 240K | /s/ Carl L. Gordon | Carl L. Gordon, Member of OrbiMed Advisors LLC | 0001808744 |
| ORBIMED CAPITAL LLC | 3.28% | 1.57M | 1.57M | 0 | /s/ Carl L. Gordon | Carl L. Gordon, Member | 0001157524 |