| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 4.5% | 1,556,369 | 0 | 1,556,369 | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001055951 |
| ORBIMED CAPITAL GP VI LLC | 1.5% | 530,487 | 0 | 530,487 | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC | 0001682115 |
| OrbiMed Capital GP VIII LLC | 2.4% | 820,707 | 0 | 820,707 | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC | 0001845804 |
| OrbiMed Genesis GP LLC | 0.6% | 205,175 | 0 | 205,175 | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC | 0001808744 |