| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 7.2% | 12,960,538 | 0 | 12,960,538 | /s/ John Legge | John Legge, Director and Chief Financial Officer | |
| Dr. Abhishek Trehan | 7.2% | 12,960,538 | 0 | 12,960,538 | /s/ Dr. Abhishek Trehan | Dr. Abhishek Trehan, individually | |
| Darwin Global Master Fund, Ltd. | 6.4% | 11,480,655 | 0 | 11,480,655 | /s/ John Legge | By: Darwin Global Management, Ltd, its Investment Manager, By: John Legge, Director and Chief Financial Officer |