FMR LLC - Dec 31, 2024 SCHEDULE 13G/A Report for UPSTREAM BIO INC COMMON STOCK (UPB)

Reporting Managers (2)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
FMR LLC	13.4%	7.18M	7.16M	0	Stephanie J. Brown	Duly authorized under Power of Attorney effective as of January 3, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Abigail P. Johnson	13.4%	7.18M	0	0	Stephanie J. Brown	Duly authorized under Power of Attorney effective as of January 26, 2023, by and on behalf of Abigail P. Johnson**

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