Insider Trading & Ownership of FMR LLC

Location
Boston, MA
Summary
The estimated value of insider holdings of FMR LLC is at least $587,512,989 dollars as of 10 Dec 2025. FMR LLC is the Other* of Flywire Corp and owns shares of Flywire Corp (FLYW) stock worth about $135,059,447. FMR LLC is the Other* of Prime Medicine, Inc. and owns shares of Prime Medicine, Inc. (PRME) stock worth about $126,699,612. FMR LLC is the Other* of Toast, Inc. and owns shares of Toast, Inc. (TOST) stock worth about $113,421,254. FMR LLC is the Other* of Neumora Therapeutics, Inc. and owns shares of Neumora Therapeutics, Inc. (NMRA) stock worth about $67,379,749. FMR LLC is the Other*, 10%+ Owner of Beam Therapeutics Inc. and owns shares of Beam Therapeutics Inc. (BEAM) stock worth about $48,071,330. FMR LLC is the Other*, 10%+ Owner of Structure Therapeutics Inc. and owns shares of Structure Therapeutics Inc. (GPCR) stock worth about $43,575,327. FMR LLC is the Other* of Bicara Therapeutics Inc. and owns shares of Bicara Therapeutics Inc. (BCAX) stock worth about $14,770,801. FMR LLC is the Other* of Rallybio Corp and owns shares of Rallybio Corp (RLYB) stock worth about $13,893,982. FMR LLC is the Other* of Caribou Biosciences, Inc. and owns shares of Caribou Biosciences, Inc. (CRBU) stock worth about $9,836,921. FMR LLC is the Other*, 10%+ Owner of Sana Biotechnology, Inc. and owns shares of Sana Biotechnology, Inc. (SANA) stock worth about $7,493,594. FMR LLC is the Other* of Verve Therapeutics, Inc. and owns shares of Verve Therapeutics, Inc. (VERV) stock worth about $5,707,290. FMR LLC is the Other* of Xilio Therapeutics, Inc. and owns shares of Xilio Therapeutics, Inc. (XLO) stock worth about $1,583,366. FMR LLC is the Other* of Fidelity Private Credit Fund and owns shares of Fidelity Private Credit Fund stock worth about $20,316.
Signature
/s/ Stephanie J. Brown, Duly authorized under Powers of Attorney, by and on behalf of FMR LLC and its direct and indirect subsidiaries, and Abigail P. Johnson
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Ownership of FMR LLC

Symbol Company Relationship Holdings Value Past Year Net Change Change % Report Period
FLYW Flywire Corp Other* $135,059,447 28 May 2021
PRME Prime Medicine, Inc. Other* $126,699,612 24 Oct 2022
TOST Toast, Inc. Other* $113,421,254 09 Nov 2021
NMRA Neumora Therapeutics, Inc. Other* $67,379,749 19 Sep 2023
BEAM Beam Therapeutics Inc. Other*, 10%+ Owner $48,071,330 -$1,003,913 -2% 27 Oct 2025
GPCR Structure Therapeutics Inc. Other*, 10%+ Owner $43,575,327 -$2,609,043 -5.6% 08 Dec 2025
BCAX Bicara Therapeutics Inc. Other* $14,770,801 16 Sep 2024
RLYB Rallybio Corp Other* $13,893,982 02 Aug 2021
CRBU Caribou Biosciences, Inc. Other* $9,836,921 27 Jul 2021
SANA Sana Biotechnology, Inc. Other*, 10%+ Owner $7,493,594 08 Jan 2025
VERV Verve Therapeutics, Inc. Other* $5,707,290 26 Jul 2022
XLO Xilio Therapeutics, Inc. Other* $1,583,366 26 Oct 2021
NONE Fidelity Private Credit Fund Other* $20,316 29 Jan 2024
MTSR Metsera, Inc. Other*, 10%+ Owner $0 -$11,817 -100% 13 Nov 2025
NONE Fidelity Multi-Strategy Credit Fund Other*, 10%+ Owner 19 May 2023
TSBX Turnstone Biologics Corp. Other* 09 Jan 2024

Insider Transactions Reported by FMR LLC:

Sym Company Class Transaction % Value $ * Price $ Shares Shares After Date Ownership
* An asterisk sign (*) next to the price indicates that the price is likely invalid.