Samir M. Gharib - 11 Dec 2025 Form 4 Insider Report for SPRUCE BIOSCIENCES, INC. (SPRB)

Reporting relationship: PRESIDENT AND CFO
Issuer ticker: SPRB
Reported as of: 11 Dec 2025
Net transaction value: $0
SEC form: 4
Accepted by SEC: 15 Dec 2025, 18:54:50 UTC
Prior SEC filing: 12 Dec 2025
Next SEC filing: 17 Dec 2025
Source filing: View source filing
Reporting owner signature: /s/ Samir Gharib

Key filing fact

Samir M. Gharib filed Form 4 for SPRUCE BIOSCIENCES, INC. (SPRB) on 15 Dec 2025.

Key facts

This page summarizes Samir M. Gharib's Form 4 filing for SPRUCE BIOSCIENCES, INC. (SPRB).
10 reported transactions and 10 derivative rows are listed below.
Accepted by SEC: 15 Dec 2025, 18:54.

Change

Previous filing in this sequence was filed on 12 Dec 2025.
Current net transaction value: $0.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001533302 Primary reporting owner

Gharib Samir M.

Relationship: PRESIDENT AND CFO
Address: C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO
Signature: /s/ Samir Gharib
Signature date: 15 Dec 2025

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

SPRB transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +1,579
Change %
Price
Shares after: 1,579
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 1,579
Exercise price: $104.13
Footnotes: F1, F2, F3

SPRB transaction Derivative

Stock Option (Right to Buy)

Disposed to Issuer

Transaction value
Shares: -1,579
Change %: -100%
Price
Shares after: 0
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 1,579
Exercise price: $123.00
Footnotes: F1, F2, F3

SPRB transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +953
Change %
Price
Shares after: 953
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 953
Exercise price: $104.13
Footnotes: F1, F2, F3

SPRB transaction Derivative

Stock Option (Right to Buy)

Disposed to Issuer

Transaction value
Shares: -953
Change %: -100%
Price
Shares after: 0
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 953
Exercise price: $230.25
Footnotes: F1, F2, F3

SPRB transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +733
Change %
Price
Shares after: 733
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 733
Exercise price: $104.13
Footnotes: F1, F2, F3

SPRB transaction Derivative

Stock Option (Right to Buy)

Disposed to Issuer

Transaction value
Shares: -733
Change %: -100%
Price
Shares after: 0
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 733
Exercise price: $1506.00
Footnotes: F1, F2, F3

SPRB transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +1,933
Change %
Price
Shares after: 1,933
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 1,933
Exercise price: $104.13
Footnotes: F2, F3, F4

SPRB transaction Derivative

Stock Option (Right to Buy)

Disposed to Issuer

Transaction value
Shares: -1,933
Change %: -100%
Price
Shares after: 0
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 1,933
Exercise price: $186.00
Footnotes: F2, F3, F4

SPRB transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +933
Change %
Price
Shares after: 933
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 933
Exercise price: $104.13
Footnotes: F2, F3, F5

SPRB transaction Derivative

Stock Option (Right to Buy)

Disposed to Issuer

Transaction value
Shares: -933
Change %: -100%
Price
Shares after: 0
Date: 11 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 933
Exercise price: $344.25
Footnotes: F2, F3, F5

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 5 footnotes

Footnote F1

The shares subject to the option are fully vested and exercisable.

Footnote F2

The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

Footnote F3

Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

Footnote F4

1/48th of the shares vest on a monthly basis from December 16, 2021, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).

Footnote F5

1/48th of the shares vest on a monthly basis from January 3, 2022, subject to Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).