Samir M. Gharib - 15 Dec 2025 Form 4 Insider Report for SPRUCE BIOSCIENCES, INC. (SPRB)

Role: PRESIDENT AND CFO
Signature: /s/ Samir Gharib
Issuer symbol: SPRB
Transactions as of: 15 Dec 2025
Net transactions value: -$29,203
Form type: 4
Filing time: 17 Dec 2025, 16:58:51 UTC
Previous filing: 15 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Gharib Samir M.	PRESIDENT AND CFO	C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO	/s/ Samir Gharib	17 Dec 2025	0001533302

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	SPRB	Common Stock	Options Exercise	$0	+496	+6.5%	$0.000000	8,112	15 Dec 2025	Direct	F1, F2
transaction	SPRB	Common Stock	Tax liability	$14,359	-178	-2.2%	$80.67	7,934	15 Dec 2025	Direct	F1
transaction	SPRB	Common Stock	Options Exercise	$0	+513	+6.5%	$0.000000	8,447	15 Dec 2025	Direct	F2, F3
transaction	SPRB	Common Stock	Tax liability	$14,843	-184	-2.2%	$80.67	8,263	15 Dec 2025	Direct	F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SPRB	Restricted Stock Units	Options Exercise	$0	-496	-50%	$0.000000	497	15 Dec 2025	Common Stock	496	$0.000000	Direct	F1, F2
transaction	SPRB	Restricted Stock Units	Options Exercise	$0	-513	-33%	$0.000000	1,027	15 Dec 2025	Common Stock	513	$0.000000	Direct	F2, F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	On December 5, 2022, the Reporting Person was granted 1,986 time-based restricted stock units ("RSUs"), subject to a 4-year vesting schedule, with 25% of the total number of RSUs vested on December 15, 2023 (the "Annual Vesting Date") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 496 RSUs vested, with 178 shares withheld for taxes, resulting in a net issuance of 318 shares.
F2	Each RSU represents a contingent right to receive one share of common stock of the Issuer.
F3	On December 14, 2023, the Reporting Person was granted a total of 4,106 RSUs. 50% or 2,053 of the total RSUs are performance-based and all vested on December 10, 2024. An addition of 50% or 2,053 of the total RSUs are time-based. 25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 513 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 329 shares.