Opaleye Management Inc. - 26 Nov 2025 Form 4/A - Amendment Insider Report for CODEXIS, INC. (CDXS)

Reporting relationship: 10%+ Owner
Issuer ticker: CDXS
Reported as of: 26 Nov 2025
Net transaction value: -$877,846
SEC form: 4/A - Amendment
Accepted by SEC: 15 Dec 2025, 06:06:27 UTC
Original report date: 01 Dec 2025
Prior SEC filing: 26 Nov 2025
Next SEC filing: 03 Dec 2025
Source filing: View source filing
Reporting owner signature: Opaleye Management Inc., By: /s/ James Silverman, President

Key filing fact

Opaleye Management Inc. filed Form 4/A - Amendment for CODEXIS, INC. (CDXS) on 15 Dec 2025.

Key facts

This page summarizes Opaleye Management Inc.'s Form 4/A - Amendment filing for CODEXIS, INC. (CDXS).
6 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 15 Dec 2025, 06:06.

Change

Previous filing in this sequence was filed on 26 Nov 2025.
Current net transaction value: -$877,846.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4/A - Amendment disclosures.

View source filing

Reporting Owners (1)

CIK 0001595855 Primary reporting owner

Opaleye Management Inc.

Relationship: 10%+ Owner
Address: ONE BOSTON PLACE, 26TH FLOOR, BOSTON
Signature: Opaleye Management Inc., By: /s/ James Silverman, President
Signature date: 15 Dec 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

CDXS transaction

Common Stock, par value $0.001 per share

Sale

Transaction value: $258,266
Shares: -148,318
Change %: -1.4%
Price: $1.74
Shares after: 10,305,000
Date: 26 Nov 2025
Ownership: By Opaleye, L.P.
Footnotes: F1, F3, F6

CDXS transaction

Common Stock, par value $0.001 per share

Sale

Transaction value: $8,706
Shares: -5,000
Change %: -2.6%
Price: $1.74
Shares after: 191,012
Date: 26 Nov 2025
Ownership: By Managed Account
Footnotes: F2, F3, F6

CDXS transaction

Common Stock, par value $0.001 per share

Sale

Transaction value: $183,750
Shares: -105,000
Change %: -1%
Price: $1.75
Shares after: 10,200,000
Date: 28 Nov 2025
Ownership: By Opaleye, L.P.
Footnotes: F1, F4, F6

CDXS transaction

Common Stock, par value $0.001 per share

Sale

Transaction value: $4,358
Shares: -2,490
Change %: -1.3%
Price: $1.75
Shares after: 188,522
Date: 28 Nov 2025
Ownership: By Managed Account
Footnotes: F2, F4, F6

CDXS transaction

Common Stock, par value $0.001 per share

Sale

Transaction value: $408,538
Shares: -245,000
Change %: -2.4%
Price: $1.67
Shares after: 9,955,000
Date: 01 Dec 2025
Ownership: By Opaleye, L.P.
Footnotes: F1, F5, F6

CDXS transaction

Common Stock, par value $0.001 per share

Sale

Transaction value: $14,229
Shares: -8,533
Change %: -4.5%
Price: $1.67
Shares after: 179,989
Date: 01 Dec 2025
Ownership: By Managed Account
Footnotes: F2, F5, F6

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 6 footnotes

Footnote F1

Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

Footnote F2

Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

Footnote F3

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.7316 - $1.75699 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

Footnote F4

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.73 - $1.7715 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

Footnote F5

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.65 - $1.7101 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price.

Footnote F6

Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC remarks

This Form 4/A is being filed to correct a clerical error in Column 4 of Table I for the transaction on 11/26/2025, which was originally reported as an acquisition ('A') and has been corrected to a disposition ('D'). No other changes have been made.