PERCEPTIVE ADVISORS LLC - 11 Nov 2025 Form 4 Insider Report for Lyra Therapeutics, Inc. (LYRA)

Reporting relationship: 10%+ Owner
Issuer ticker: LYRA
Reported as of: 11 Nov 2025
Net transaction value: -$182,515
SEC form: 4
Accepted by SEC: 13 Nov 2025, 17:07:48 UTC
Prior SEC filing: 10 Nov 2025
Next SEC filing: 23 Dec 2025
Source filing: View source filing
Reporting owner signature: /s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member

Key filing fact

PERCEPTIVE ADVISORS LLC filed Form 4 for Lyra Therapeutics, Inc. (LYRA) on 13 Nov 2025.

Key facts

This page summarizes PERCEPTIVE ADVISORS LLC's Form 4 filing for Lyra Therapeutics, Inc. (LYRA).
6 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 13 Nov 2025, 17:07.

Change

Previous filing in this sequence was filed on 10 Nov 2025.
Current net transaction value: -$182,515.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (4)

CIK 0001224962 Primary reporting owner

PERCEPTIVE ADVISORS LLC

Relationship: 10%+ Owner
Address: 51 ASTOR PLACE, 10TH FLOOR, NEW YORK
Signature: /s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member
Signature date: 13 Nov 2025

CIK 0001249675

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD

Relationship: 10%+ Owner
Address: 51 ASTOR PLACE, 10TH FLOOR, NEW YORK
Signature: /s/ Joseph Edelman - for Perceptive LS (A), LLC, By: Perceptive LS GP, LLC, its General Partner, By: Joseph Edelman, its sole member
Signature date: 13 Nov 2025

CIK 0001797811

Perceptive LS (A), LLC

Relationship: 10%+ Owner
Address: 51 ASTOR PLACE, 10TH FLOOR, NEW YORK
Signature: /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member
Signature date: 13 Nov 2025

CIK 0001164426

EDELMAN JOSEPH

Relationship: 10%+ Owner
Address: 51 ASTOR PLACE, 10TH FLOOR, NEW YORK
Signature: /s/ Joseph Edelman
Signature date: 13 Nov 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

LYRA transaction

Common Stock

Sale

Transaction value: $20,637
Shares: -4,783
Change %: -2.9%
Price: $4.31
Shares after: 161,318
Date: 11 Nov 2025
Ownership: See Footnotes
Footnotes: F1, F2, F3

LYRA transaction

Common Stock

Sale

Transaction value: $2,317
Shares: -537
Change %: -2.9%
Price: $4.31
Shares after: 18,122
Date: 11 Nov 2025
Ownership: See Footnotes
Footnotes: F1, F2, F4

LYRA transaction

Common Stock

Sale

Transaction value: $31,915
Shares: -7,862
Change %: -4.9%
Price: $4.06
Shares after: 153,456
Date: 12 Nov 2025
Ownership: See Footnotes
Footnotes: F2, F3, F5

LYRA transaction

Common Stock

Sale

Transaction value: $3,584
Shares: -883
Change %: -4.9%
Price: $4.06
Shares after: 17,239
Date: 12 Nov 2025
Ownership: See Footnotes
Footnotes: F2, F4, F5

LYRA transaction

Common Stock

Sale

Transaction value: $111,531
Shares: -28,597
Change %: -19%
Price: $3.90
Shares after: 124,859
Date: 13 Nov 2025
Ownership: See Footnotes
Footnotes: F2, F3, F6

LYRA transaction

Common Stock

Sale

Transaction value: $12,531
Shares: -3,213
Change %: -19%
Price: $3.90
Shares after: 14,026
Date: 13 Nov 2025
Ownership: See Footnotes
Footnotes: F2, F4, F6

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Section 16 status

PERCEPTIVE ADVISORS LLC is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may still apply in specific circumstances.

Explanation of responses 6 footnotes

Footnote F1

The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.25 to $4.61 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within such range.

Footnote F2

Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund"). Perceptive LS GP, LLC ("GP") is the manager of Perceptive LS (A), LLC ("Perceptive LS"). Joseph Edelman is the managing member of the Advisor and the sole member of GP. Each of Mr. Edelman, GP and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman, GP or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

Footnote F3

The securities reported in this row are held by the Master Fund.

Footnote F4

The securities reported in this row are held by Perceptive LS.

Footnote F5

The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.90 to $4.27 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within such range.

Footnote F6

The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.90 to $3.91 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within such range.