Uwe Klein - 18 Aug 2025 Form 4 Insider Report for Septerna, Inc. (SEPN)

Reporting relationship: SVP, Biological Sciences
Issuer ticker: SEPN
Reported as of: 18 Aug 2025
Net transaction value: +$94,367
SEC form: 4
Accepted by SEC: 19 Aug 2025, 17:02:20 UTC
Prior SEC filing: 11 Aug 2025
Next SEC filing: 10 Feb 2026
Source filing: View source filing
Reporting owner signature: /s/ Ran Xiao, Attorney-in-Fact

Key filing fact

Uwe Klein filed Form 4 for Septerna, Inc. (SEPN) on 19 Aug 2025.

Key facts

This page summarizes Uwe Klein's Form 4 filing for Septerna, Inc. (SEPN).
6 reported transactions and 3 derivative rows are listed below.
Accepted by SEC: 19 Aug 2025, 17:02.

Change

Previous filing in this sequence was filed on 11 Aug 2025.
Current net transaction value: +$94,367.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0002040350 Primary reporting owner

Klein Uwe

Relationship: SVP, Biological Sciences
Address: C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO
Signature: /s/ Ran Xiao, Attorney-in-Fact
Signature date: 19 Aug 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

SEPN transaction

Common Stock

Options Exercise

Transaction value: $28,848
Shares: +10,452
Change %
Price: $2.76
Shares after: 10,452
Date: 18 Aug 2025
Ownership: Direct

SEPN transaction

Common Stock

Options Exercise

Transaction value: $13,621
Shares: +4,935
Change %: +47%
Price: $2.76
Shares after: 15,387
Date: 18 Aug 2025
Ownership: Direct

SEPN transaction

Common Stock

Options Exercise

Transaction value: $51,899
Shares: +7,621
Change %: +50%
Price: $6.81
Shares after: 23,008
Date: 18 Aug 2025
Ownership: Direct

SEPN holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 104,525
Date: 18 Aug 2025
Ownership: See footnote
Footnotes: F1

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

SEPN transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value: $0
Shares: -10,452
Change %: -50%
Price: $0.000000
Shares after: 10,453
Date: 18 Aug 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 10,452
Exercise price: $2.76
Footnotes: F2

SEPN transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value: $0
Shares: -4,935
Change %: -35%
Price: $0.000000
Shares after: 9,001
Date: 18 Aug 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 4,935
Exercise price: $2.76
Footnotes: F3

SEPN transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value: $0
Shares: -7,621
Change %: -19%
Price: $0.000000
Shares after: 33,027
Date: 18 Aug 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 7,621
Exercise price: $6.81
Footnotes: F4

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 4 footnotes

Footnote F1

Shares held by Klein 2024 Revocable Trust dated February 25, 2024 (the "Trust), of which the Reporting Person is a co-trustee. The Reporting Person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

Footnote F2

1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date.

Footnote F3

1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

Footnote F4

1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, contingent upon the consummation of the Issuer's initial public offering, and subject to the Reporting Person's continuous service to the Issuer on each such date.