Uwe Klein - 06 Feb 2026 Form 4 Insider Report for Septerna, Inc. (SEPN)

Role
SVP, Biological Sciences
Signature
/s/ Mark A. Wilson, Attorney-in-Fact
Issuer symbol
SEPN
Transactions as of
06 Feb 2026
Net transactions value
$0
Form type
4
Filing time
10 Feb 2026, 19:15:35 UTC
Previous filing
19 Aug 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Klein Uwe SVP, Biological Sciences C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO /s/ Mark A. Wilson, Attorney-in-Fact 10 Feb 2026 0002040350

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction SEPN Stock Option (Right to Buy) Award $0 +80,000 $0.000000 80,000 06 Feb 2026 Common Stock 80,000 $25.41 Direct F1
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

Remarks:

Exhibit 24.2 - Substitute Power of Attorney