Brian J. Brille - 06 Mar 2026 Form 4 Insider Report for Caris Life Sciences, Inc. (CAI)

Role: Vice Chairman and Executive Vice President, Director
Signature: /s/ J. Russel Denton, Attorney-in-Fact
Issuer symbol: CAI
Transactions as of: 06 Mar 2026
Net transactions value: $0
Form type: 4
Filing time: 10 Mar 2026, 17:59:34 UTC
Previous filing: 12 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Brille Brian J	Vice Chairman and Executive Vice President, Director	C/O CARIS LIFE SCIENCES, INC., 750 W. JOHN CARPENTER FREEWAY, SUITE 800, IRVING	/s/ J. Russel Denton, Attorney-in-Fact	10 Mar 2026	0002071959

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CAI	Common Stock	Award		+83,162	+52%	$0.000000^*	244,290	06 Mar 2026	Direct	F1
holding	CAI	Common Stock						500,000	06 Mar 2026	By Trust	F2, F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents an award of restricted stock units which vest in accordance with the applicable grant agreement.
F2	The Reporting Person disclaims beneficial ownership except to the extent of his pecuniary interest therein.
F3	By a family trust, with shares previously held in multiple family trusts consolidated into a single trust.

Remarks:

Vice Chairman and Executive Vice President