Brian J. Brille - 10 Dec 2025 Form 4 Insider Report for Caris Life Sciences, Inc.

Role: Vice Chairman and Executive Vice President, Director
Signature: /s/ J. Russel Denton, Attorney-in-Fact
Issuer symbol: CAI on Nasdaq
Transactions as of: 10 Dec 2025
Net transactions value: $0
Form type: 4
Filing time: 12 Dec 2025, 18:22:53 UTC
Previous filing: 23 Jun 2025
Next filing: 10 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Brille Brian J	Vice Chairman and Executive Vice President, Director	C/O CARIS LIFE SCIENCES, INC., 750 W. JOHN CARPENTER FREEWAY, SUITE 800, IRVING	/s/ J. Russel Denton, Attorney-in-Fact	12 Dec 2025	0002071959

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CAI	Common Stock	Gift	$0	-650	-0.4%	$0.000000	161,778	10 Dec 2025	Direct
transaction	CAI	Common Stock	Gift	$0	-650	-0.4%	$0.000000	161,128	11 Dec 2025	Direct
holding	CAI	Common Stock						500,000	10 Dec 2025	By Trusts	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The Reporting Person disclaims beneficial ownership except to the extent of his pecuniary interest therein.

Remarks:

Vice Chairman and Executive Vice President