| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Rangwala Reshma | EVP & Chief Medical Officer | C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE, NEWTON | /s/ Nancy Smith as Attorney-in-Fact for Reshma Rangwala | 03 Mar 2026 | 0001825322 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | KPTI | Common Stock | Sale | $47,669 | -5,066 | -8.2% | $9.41 | 56,739 | 02 Mar 2026 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on April 4, 2022, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person. |