| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Watts Ryan J. | President and CEO, Director | C/O DENALI THERAPEUTICS INC., 161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO | /s/ Tyler Nielsen, by power of attorney | 05 Jan 2026 | 0001724310 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DNLI | Common Stock | Award | $0 | +78,960 | +31% | $0.000000 | 332,031 | 03 Jan 2026 | Direct | F1, F2 |
| holding | DNLI | Common Stock | 2,152,604 | 03 Jan 2026 | See footnote | F3 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DNLI | Stock Option (right to buy) | Award | $0 | +236,880 | $0.000000 | 236,880 | 03 Jan 2026 | Common Stock | 236,880 | $16.27 | Direct | F4 |
| Id | Content |
|---|---|
| F1 | Each share is represented by a Restricted Stock Unit ("RSU") and a contingent right to receive one share of common stock of the Issuer. 25% of the RSUs shall vest on January 3, 2027 (the "Vesting Commencement Date") and an additional 25% of the RSUs shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date. |
| F2 | Includes 184,915 Unvested RSUs. |
| F3 | The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee. |
| F4 | 25% of the shares subject to the option shall vest on January 3, 2027, and 1/48 of the shares subject to the option shall vest each month thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date |