| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Watts Ryan J. | President and CEO, Director | C/O DENALI THERAPEUTICS INC., 161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO | /s/ Tyler Nielsen, by power of attorney | 08 Jan 2026 | 0001724310 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DNLI | Common Stock | Sale | $580,767 | -35,198 | -11% | $16.50 | 296,833 | 06 Jan 2026 | Direct | F1, F2 |
| holding | DNLI | Common Stock | 2,152,604 | 06 Jan 2026 | See footnote | F3 |
| Id | Content |
|---|---|
| F1 | Shares sold to satisfy the tax obligations by the Reporting Person in connection with the settlement of previously vested RSUs. |
| F2 | Includes 184,915 Unvested RSUs. |
| F3 | The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee. |