Opaleye Management Inc. - 26 Feb 2026 Form 4 Insider Report for Alpha Cognition Inc. (ACOG)

Role: 10%+ Owner
Signature: Opaleye Management Inc., By: /s/ James Silverman, President
Issuer symbol: ACOG
Transactions as of: 26 Feb 2026
Net transactions value: +$25,328
Form type: 4
Filing time: 02 Mar 2026, 16:05:09 UTC
Previous filing: 24 Feb 2026
Next filing: 03 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Opaleye Management Inc.	10%+ Owner	ONE BOSTON PLACE, 26TH FLOOR, BOSTON	Opaleye Management Inc., By: /s/ James Silverman, President	02 Mar 2026	0001595855

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ACOG	Common Stock, no par value	Purchase	$3,531	+590	+0.03%	$5.98	2,285,000	26 Feb 2026	By Opaleye, L.P.	F1, F3, F5
transaction	ACOG	Common Stock, no par value	Purchase	$21,797	+3,638	+0.16%	$5.99	2,288,638	27 Feb 2026	By Opaleye, L.P.	F1, F4, F5
holding	ACOG	Common Stock, no par value						80,000	26 Feb 2026	By Managed Account	F2, F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.
F2	Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.
F3	The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.975 to $6.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
F4	The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.975 to $6.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.
F5	Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.