PETER M. CASTLEMAN - 26 Feb 2026 Form 4 Insider Report for Caris Life Sciences, Inc. (CAI)

Role: Director
Signature: /s/ J. Russel Denton, Attorney-in-Fact
Issuer symbol: CAI
Transactions as of: 26 Feb 2026
Net transactions value: +$110,511
Form type: 4
Filing time: 27 Feb 2026, 18:07:35 UTC
Previous filing: 13 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
CASTLEMAN PETER M	Director	C/O CARIS LIFE SCIENCES, INC., 750 W. JOHN CARPENTER FREEWAY, SUITE 800, IRVING	/s/ J. Russel Denton, Attorney-in-Fact	27 Feb 2026	0001239594

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CAI	Common Stock	Award	$110,511	+5,509	+30%	$20.06	24,138	26 Feb 2026	Direct	F1
holding	CAI	Common Stock						100,000	26 Feb 2026	By Family Trust
holding	CAI	Common Stock						10,270,906	26 Feb 2026	By CLS-PF-SPE, LLC	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Shares issued in lieu of cash compensation for 2025 board retainer fees. Number of shares determined by dividing the cash retainer earned by the ten trading day average of the daily volume weighted average price per share through and including February 25, 2026.
F2	CLS-PF-SPE Manager, LLC is the manager of CLS-PF-SPE, LLC. Mr. Castleman is a manager of CLS-PF-SPE Manager, LLC and in such capacity has voting and investment power with respect to the shares held by CLS-PF-SPE, LLC. The Reporting Person disclaims beneficial ownership except to the extent of his pecuniary interest therein.