| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| CASTLEMAN PETER M | Director | C/O CARIS LIFE SCIENCES, INC., 750 W. JOHN CARPENTER FREEWAY, SUITE 800, IRVING | /s/ J. Russel Denton, Attorney-in-Fact | 13 Jan 2026 | 0001239594 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | CAI | Common Stock | Options Exercise | $46,500 | +2,500 | +16% | $18.60 | 18,629 | 09 Jan 2026 | Direct | |
| holding | CAI | Common Stock | 100,000 | 09 Jan 2026 | By Family Trust | ||||||
| holding | CAI | Common Stock | 10,270,906 | 09 Jan 2026 | By CLS-PF-SPE, LLC | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | CAI | Stock Option | Options Exercise | $0 | -2,500 | -100% | $0.000000 | 0 | 09 Jan 2026 | Common Stock | 2,500 | $18.60 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | CLS-PF-SPE Manager, LLC is the manager of CLS-PF-SPE, LLC. Mr. Castleman is a manager of CLS-PF-SPE Manager, LLC and in such capacity has voting and investment power with respect to the shares held by CLS-PF-SPE, LLC. The Reporting Person disclaims beneficial ownership except to the extent of his pecuniary interest therein. |
| F2 | The stock option is fully vested and exercisable. These securities were previously reported on the Reporting Person's Form 3. |