| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 10%+ Owner | 51 ASTOR PLACE, 10TH FLOOR, NEW YORK | /s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member | 13 Nov 2025 | 0001224962 |
| PERCEPTIVE LIFE SCIENCES MASTER FUND LTD | 10%+ Owner | 51 ASTOR PLACE, 10TH FLOOR, NEW YORK | /s/ Joseph Edelman - for Perceptive LS (A), LLC, By: Perceptive LS GP, LLC, its General Partner, By: Joseph Edelman, its sole member | 13 Nov 2025 | 0001249675 |
| Perceptive LS (A), LLC | 10%+ Owner | 51 ASTOR PLACE, 10TH FLOOR, NEW YORK | /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member | 13 Nov 2025 | 0001797811 |
| EDELMAN JOSEPH | 10%+ Owner | 51 ASTOR PLACE, 10TH FLOOR, NEW YORK | /s/ Joseph Edelman | 13 Nov 2025 | 0001164426 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | LYRA | Common Stock | Sale | $20,637 | -4,783 | -2.9% | $4.31 | 161,318 | 11 Nov 2025 | See Footnotes | F1, F2, F3 |
| transaction | LYRA | Common Stock | Sale | $2,317 | -537 | -2.9% | $4.31 | 18,122 | 11 Nov 2025 | See Footnotes | F1, F2, F4 |
| transaction | LYRA | Common Stock | Sale | $31,915 | -7,862 | -4.9% | $4.06 | 153,456 | 12 Nov 2025 | See Footnotes | F2, F3, F5 |
| transaction | LYRA | Common Stock | Sale | $3,584 | -883 | -4.9% | $4.06 | 17,239 | 12 Nov 2025 | See Footnotes | F2, F4, F5 |
| transaction | LYRA | Common Stock | Sale | $111,531 | -28,597 | -19% | $3.90 | 124,859 | 13 Nov 2025 | See Footnotes | F2, F3, F6 |
| transaction | LYRA | Common Stock | Sale | $12,531 | -3,213 | -19% | $3.90 | 14,026 | 13 Nov 2025 | See Footnotes | F2, F4, F6 |
PERCEPTIVE ADVISORS LLC is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may continue.
| Id | Content |
|---|---|
| F1 | The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.25 to $4.61 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within such range. |
| F2 | Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund"). Perceptive LS GP, LLC ("GP") is the manager of Perceptive LS (A), LLC ("Perceptive LS"). Joseph Edelman is the managing member of the Advisor and the sole member of GP. Each of Mr. Edelman, GP and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman, GP or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. |
| F3 | The securities reported in this row are held by the Master Fund. |
| F4 | The securities reported in this row are held by Perceptive LS. |
| F5 | The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.90 to $4.27 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within such range. |
| F6 | The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.90 to $3.91 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within such range. |