FMR LLC - 10 Nov 2025 Form 4 Insider Report for Metsera, Inc. (MTSR)

Signature
/s/ Stephanie J. Brown, Duly authorized under Powers of Attorney, by and on behalf of FMR LLC and its direct and indirect subsidiaries, and Abigail P. Johnson
Issuer symbol
MTSR
Transactions as of
10 Nov 2025
Net transactions value
$0
Form type
4
Filing time
12 Nov 2025, 10:48:53 UTC
Previous filing
05 Nov 2025
Next filing
17 Nov 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
FMR LLC Other*, 10%+ Owner 245 SUMMER STREET, BOSTON /s/ Stephanie J. Brown, Duly authorized under Powers of Attorney, by and on behalf of FMR LLC and its direct and indirect subsidiaries, and Abigail P. Johnson 12 Nov 2025 0000315066

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction MTSR Common Stock Gift $0 -860,722 -28% $0.000000 2,230,450 10 Nov 2025 Shares held by persons and entities whose shares are subject to reporting by the undersigned.
holding MTSR Common Stock 3,010 10 Nov 2025 F-Prime Inc.
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Remarks:

Remark 1: Abigail P. Johnson is a Director, the Chairman and the Chief Executive Officer of FMR LLC. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. The address of Abigail P. Johnson is c/o FMR LLC, 245 Summer Street, Boston, MA 02110. Remark 2: The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the undersigned are the beneficial owners of any securities reported herein. Remark 3: F-Prime Inc. is a wholly-owned subsidiary of FMR LLC.