Keith Michael Gottesdiener - 25 Sep 2025 Form 4 Insider Report for Septerna, Inc. (SEPN)

Role: Director
Signature: /s/ Gil M. Labrucherie, Attorney-in-Fact
Issuer symbol: SEPN
Transactions as of: 25 Sep 2025
Net transactions value: $0
Form type: 4
Filing time: 29 Sep 2025, 16:59:05 UTC
Previous filing: 12 May 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Gottesdiener Keith Michael	Director	C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO	/s/ Gil M. Labrucherie, Attorney-in-Fact	29 Sep 2025	0001615856

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SEPN	Stock Option (Right to Buy)	Award	$0	+33,246		$0.000000	33,246	25 Sep 2025	Common Stock	33,246	$16.75	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	1/36th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of September 25, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.