Keith Michael Gottesdiener - 08 May 2025 Form 4 Insider Report for Prime Medicine, Inc. (PRME)

Role: Exhibit 24 - Power of Attorney; Title: President and Chief Executive Officer, Director
Signature: /s/ Ryan Brown, attorney-in-fact
Issuer symbol: PRME
Transactions as of: 08 May 2025
Transactions value $: $0
Form type: 4
Filing time: 12 May 2025, 16:50:03 UTC
Previous filing: 04 Mar 2025
Next filing: 29 Sep 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Gottesdiener Keith Michael	Exhibit 24 - Power of Attorney; Title: President and Chief Executive Officer, Director	C/O PRIME MEDICINE, INC., 60 FIRST STREET, CAMBRIDGE	/s/ Ryan Brown, attorney-in-fact	12 May 2025	0001615856

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PRME	Stock Option (right to buy)	Award	$0	+100K	+50%	$0.00	300K	08 May 2025	Common Stock	100K	$8.32	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents an option initially granted to the Reporting Person on February 25, 2024, a portion of which shares underlying this option shall vest upon the achievement of certain performance milestones. On May 8, 2025, the board of directors of the Issuer determined that one of the performance milestone conditions was achieved, resulting in the vesting of 100,000 shares.

Remarks:

Exhibit 24 - Power of Attorney; Title: President and Chief Executive Officer