Perceptive Advisors Llc - Apr 12, 2022 Form 4 Insider Report for Lyra Therapeutics, Inc. (LYRA)

Role: Director, 10%+ Owner
Signature: /s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member
Stock symbol: LYRA
Transactions as of: Apr 12, 2022
Transactions value $: $24,999,997
Form type: 4
Date filed: 4/14/2022, 04:53 PM
Previous filing: Dec 10, 2021
Next filing: Apr 18, 2022

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	LYRA	Common Stock	Purchase	$25M	+5.92M	+306.3%	$4.22	7.86M	Apr 12, 2022	See Footnotes	F1, F3
holding	LYRA	Common Stock						1.29M	Apr 12, 2022	See Footnotes	F2, F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The securities reported in this row are held by Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund").
F2	The securities reported in this row are held by Perceptive LS (A), LLC ("Perceptive LS").
F3	Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to the Master Fund. Perceptive LS GP, LLC ("GP") is the manager of Perceptive LS. Joseph Edelman is the managing member of the Advisor and the sole member of GP. Each of Mr. Edelman, GP and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman, GP or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.