Perceptive Advisors Llc - Oct 7, 2021 Form 3 Insider Report for IsoPlexis Corp (ISO)

Role: 10%+ Owner
Signature: /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member
Stock symbol: ISO
Transactions as of: Oct 7, 2021
Transactions value $: $0
Form type: 3
Date filed: 10/7/2021, 05:27 PM
Previous filing: Sep 30, 2021
Next filing: Oct 14, 2021

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
holding	ISO	Series D Redeemable Convertible Preferred Stock							Oct 7, 2021	Common Stock	2.6M		By Perceptive Life Sciences Master Fund, Ltd.	F1, F3
holding	ISO	Series D Redeemable Convertible Preferred Stock							Oct 7, 2021	Common Stock	323K		By Perceptive Credit Holdings III, LP	F1, F4
holding	ISO	Series D Redeemable Convertible Preferred Stock							Oct 7, 2021	Common Stock	197K		By PCOF EQ AIV III, LP	F1, F5
holding	ISO	Series D Preferred Stock Warrant							Oct 7, 2021	Common Stock	780K		By Perceptive Credit Holdings III, LP	F2, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Shares of Series D Redeemable Convertible Preferred Stock, par value $0.001, of the Issuer (the "Preferred Stock") convert on a one-for-eight basis into shares of Common Stock of the Issuer at the option of the holder at any time and convert automatically upon the closing of the Issuer's initial public offering (the "IPO"). The Preferred Stock has no expiration date.
F2	The Series D Preferred Stock Warrant (the "Warrant") was initially issued on December 30, 2021, and is exercisable at an exercise price equal to $76.92 per share of Preferred Stock. The Warrant expires at 5:00 p.m., Eastern time, on the tenth anniversary of the issue date. Upon the closing of the IPO, the Warrant will become exercisable for shares of the Issuer's Common Stock at an exercise price of $9.615 per share.
F3	The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. ("Master Fund"). Perceptive Advisors LLC (the "Advisor") is the investment manager of the Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.
F4	The securities are directly held by Perceptive Credit Holdings III, LP ("PCH III"). Perceptive Credit Advisors, LLC ("Perceptive Credit") is the investment manager to PCH III. Joseph Edelman is the managing member of Perceptive Credit. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.
F5	The securities are directly held by PCOF EQ AIV III, LP ("PCOF"). Perceptive Credit is the investment manager to PCOF. Joseph Edelman is the managing member of Perceptive Credit. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.