Jeffrey M. Leiden - 22 Jan 2026 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Role: Executive Chairman, Director
Signature: /s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol: VRTX
Transactions as of: 22 Jan 2026
Net transactions value: $0
Form type: 4
Filing time: 26 Jan 2026, 16:28:06 UTC
Previous filing: 05 Dec 2025
Next filing: 19 Feb 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
LEIDEN JEFFREY M	Executive Chairman, Director	C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON	/s/ Christiana Stevenson, Attorney-in-Fact	26 Jan 2026	0001242825

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	VRTX	Common Stock	Award	$0	+9,012	+38%	$0.000000	33,039	22 Jan 2026	Direct	F1
holding	VRTX	Common Stock						440	22 Jan 2026	401(k)

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents earned performance shares with respect to a performance stock unit award granted on 02/12/2025 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 01/22/2026 and the shares will vest on 02/24/2026.