Jeffrey M. Leiden - 03 Dec 2025 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Signature
/s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol
VRTX
Transactions as of
03 Dec 2025
Net transactions value
-$23,131,913
Form type
4
Filing time
05 Dec 2025, 16:10:39 UTC
Previous filing
17 Nov 2025
Next filing
26 Jan 2026

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
LEIDEN JEFFREY M Executive Chairman, Director C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON /s/ Christiana Stevenson, Attorney-in-Fact 05 Dec 2025 0001242825

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction VRTX Common Stock Options Exercise $5,518,332 +63,781 +265% $86.52 87,807 03 Dec 2025 Direct
transaction VRTX Common Stock Sale $1,968,148 -4,469 -5.1% $440.40 83,338 03 Dec 2025 Direct F1, F2, F3
transaction VRTX Common Stock Sale $582,463 -1,320 -1.6% $441.26 82,018 03 Dec 2025 Direct F1, F2, F4
transaction VRTX Common Stock Sale $1,094,285 -2,469 -3% $443.21 79,549 03 Dec 2025 Direct F1, F2, F5
transaction VRTX Common Stock Sale $1,933,855 -4,352 -5.5% $444.36 75,197 03 Dec 2025 Direct F1, F2, F6
transaction VRTX Common Stock Sale $3,519,478 -7,899 -11% $445.56 67,298 03 Dec 2025 Direct F1, F2, F7
transaction VRTX Common Stock Sale $515,002 -1,152 -1.7% $447.05 66,146 03 Dec 2025 Direct F1, F2, F8
transaction VRTX Common Stock Sale $1,041,170 -2,320 -3.5% $448.78 63,826 03 Dec 2025 Direct F1, F2, F9
transaction VRTX Common Stock Sale $2,645,059 -5,880 -9.2% $449.84 57,946 03 Dec 2025 Direct F1, F2, F10
transaction VRTX Common Stock Sale $2,621,021 -5,809 -10% $451.20 52,137 03 Dec 2025 Direct F1, F2, F11
transaction VRTX Common Stock Sale $7,090,948 -15,681 -30% $452.20 36,456 03 Dec 2025 Direct F1, F2, F12
transaction VRTX Common Stock Sale $4,696,602 -10,360 -28% $453.34 26,096 03 Dec 2025 Direct F1, F2, F13
transaction VRTX Common Stock Sale $942,305 -2,070 -7.9% $455.22 24,026 03 Dec 2025 Direct F1, F2, F14
transaction VRTX Common Stock Options Exercise $91.05 +1 +0% $91.05 24,027 04 Dec 2025 Direct
holding VRTX Common Stock 440 03 Dec 2025 401(k)

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction VRTX Stock Option (Right to Buy) Options Exercise $0 -63,781 -100% $0.000000 0 03 Dec 2025 Common Stock 63,781 $86.52 Direct F15
transaction VRTX Stock Option (Right to Buy) Options Exercise $0 -1 -100% $0.000000 0 04 Dec 2025 Common Stock 1 $91.05 Direct F15
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025.
F2 Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
F3 Open market sales reported on this line occurred at a weighted average price of $440.40 (range $440.04 to $441.00).
F4 Open market sales reported on this line occurred at a weighted average price of $441.26 (range $441.14 to $442.00).
F5 Open market sales reported on this line occurred at a weighted average price of $443.21 (range $442.94 to $443.93).
F6 Open market sales reported on this line occurred at a weighted average price of $444.36 (range $444.00 to $444.94).
F7 Open market sales reported on this line occurred at a weighted average price of $445.56 (range $445.00 to $445.82).
F8 Open market sales reported on this line occurred at a weighted average price of $447.05 (range $447.00 to $447.23).
F9 Open market sales reported on this line occurred at a weighted average price of $448.78 (range $448.18 to $449.12).
F10 Open market sales reported on this line occurred at a weighted average price of $449.84 (range $449.22 to $450.18).
F11 Open market sales reported on this line occurred at a weighted average price of $451.20 (range $450.71 to $451.70).
F12 Open market sales reported on this line occurred at a weighted average price of $452.20 (range $451.73 to $452.69).
F13 Open market sales reported on this line occurred at a weighted average price of $453.34 (range $452.91 to $453.70).
F14 Open market sales reported on this line occurred at a weighted average price of $455.22 (range $454.88 to $455.66).
F15 Fully vested.