Jeffrey M. Leiden - 13 Nov 2025 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Signature
/s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol
VRTX
Transactions as of
13 Nov 2025
Net transactions value
-$25,799,237
Form type
4
Filing time
17 Nov 2025, 16:12:06 UTC
Previous filing
19 Feb 2025
Next filing
05 Dec 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
LEIDEN JEFFREY M Executive Chairman, Director C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON /s/ Christiana Stevenson, Attorney-in-Fact 17 Nov 2025 0001242825

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction VRTX Common Stock Options Exercise $1,792,592 +19,688 +82% $91.05 43,714 13 Nov 2025 Direct
transaction VRTX Common Stock Sale $8,156,396 -18,528 -42% $440.22 25,186 13 Nov 2025 Direct F1, F2, F3
transaction VRTX Common Stock Sale $511,618 -1,160 -4.6% $441.05 24,026 13 Nov 2025 Direct F1, F2, F4
transaction VRTX Common Stock Options Exercise $1,259,677 +13,835 +58% $91.05 37,861 14 Nov 2025 Direct
transaction VRTX Common Stock Options Exercise $3,440,814 +39,769 +105% $86.52 77,630 14 Nov 2025 Direct
transaction VRTX Common Stock Sale $14,192,630 -32,234 -42% $440.30 45,396 14 Nov 2025 Direct F1, F2, F5
transaction VRTX Common Stock Sale $9,413,996 -21,330 -47% $441.35 24,066 14 Nov 2025 Direct F1, F2, F6
transaction VRTX Common Stock Sale $17,680 -40 -0.17% $442.00 24,026 14 Nov 2025 Direct F1
holding VRTX Common Stock 440 13 Nov 2025 401(k)

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction VRTX Stock Option (Right to Buy) Options Exercise $0 -19,688 -59% $0.000000 13,836 13 Nov 2025 Common Stock 19,688 $91.05 Direct F7
transaction VRTX Stock Option (Right to Buy) Options Exercise $0 -13,835 -100% $0.000000 1 14 Nov 2025 Common Stock 13,835 $91.05 Direct F7
transaction VRTX Stock Option (Right to Buy) Options Exercise $0 -39,769 -38% $0.000000 63,781 14 Nov 2025 Common Stock 39,769 $86.52 Direct F7
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025.
F2 Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
F3 Open market sales reported on this line occurred at a weighted average price of $440.22 (range $440.00 to $440.99).
F4 Open market sales reported on this line occurred at a weighted average price of $441.05 (range $441.00 to $441.10).
F5 Open market sales reported on this line occurred at a weighted average price of $440.30 (range $440.00 to $440.99).
F6 Open market sales reported on this line occurred at a weighted average price of $441.35 (range $441.00 to $441.99).
F7 Fully vested.