Frederick T. Muto - Jul 1, 2022 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Director
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Frederick T. Muto
Stock symbol: IONS
Transactions as of: Jul 1, 2022
Transactions value $: $145,575
Form type: 4
Date filed: 7/6/2022, 05:25 PM
Previous filing: Jul 19, 2021
Next filing: Jul 19, 2022

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Options Exercise	$146K	+11.3K	+27.88%	$12.94	51.6K	Jul 1, 2022	Direct	F1
holding	IONS	Common Stock						1.5K	Jul 1, 2022	By Cooley Pen Plan

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Non-Qualified Stock Option (right to buy)	Options Exercise	$0	-11.3K	-100%	$0.00^*	0	Jul 1, 2022	Common Stock	11.3K	$12.94	Direct
transaction	IONS	Non-Qualified Stock Option (right to buy)	Award	$0	+12K		$0.00	12K	Jul 1, 2022	Common Stock	12K	$38.06	Direct	F2
transaction	IONS	Restricted Stock Unit	Award	$0	+5.33K	+54.56%	$0.00	15.1K	Jul 1, 2022	Common Stock	5.33K	$0.00	Direct	F3, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2022.
F2	Grant on July 1, 2022 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2022.
F3	Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
F4	Grant on July 1, 2022 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2022.