Frederick T. Muto - 15 Jul 2021 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Director
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Frederick T. Muto
Issuer symbol: IONS
Transactions as of: 15 Jul 2021
Net transactions value: $0
Form type: 4
Filing time: 19 Jul 2021, 20:15:19 UTC
Previous filing: 06 Jul 2021
Next filing: 06 Jul 2022
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Options Exercise	$0	+5,333	+17%	$0.000000	37,016	15 Jul 2021	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+889	+2.4%	$0.000000	37,905	15 Jul 2021	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+666	+1.8%	$0.000000	38,571	15 Jul 2021	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+1,778	+4.6%	$0.000000	40,349	15 Jul 2021	Direct	F1
holding	IONS	Common Stock						1,500	15 Jul 2021	By Cooley Pen Plan

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-5,333	-29%	$0.000000	13,108	15 Jul 2021	Common Stock	5,333	$0.000000	Direct	F2, F3
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-889	-6.8%	$0.000000	12,219	15 Jul 2021	Common Stock	889	$0.000000	Direct	F2, F4
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-666	-5.5%	$0.000000	11,553	15 Jul 2021	Common Stock	666	$0.000000	Direct	F2, F4
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-1,778	-15%	$0.000000	9,775	15 Jul 2021	Common Stock	1,778	$0.000000	Direct	F2, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.
F2	Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
F3	Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.
F4	Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.