EcoR1 Capital, LLC

Holdings History for Apellis Pharmaceuticals, Inc. - Common Stock, $0.0001 par value (APLS)

Symbol: APLS on Nasdaq
Investment type: Equity / Common Stock, $0.0001 par value
Latest Disclosed Shares Owned: 3,447,156 shares
Security Ownership %: 2.7%

Shares, Excluding Options vs Price

Value, Excluding Options

EcoR1 Capital, LLC ownership in Apellis Pharmaceuticals, Inc. Common Stock, $0.0001 par value (APLS)

14 Nov 2025 - EcoR1 Capital, LLC has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 3,447,156 shares of Apellis Pharmaceuticals, Inc. Common Stock, $0.0001 par value (APLS). This represents 2.7% ownership of the company. This is the first filing by EcoR1 Capital, LLC disclosing ownership of Apellis Pharmaceuticals, Inc. Common Stock, $0.0001 par value (APLS).

Reporting Name	Ownership %	Change	Value $	Shares owned	Change	Activity %	Price	Form	Report date	Filing time
EcoR1 Capital, LLC	2.7%		$78,009,140	3,447,156			$22.63	13G/A	30 Sep 2025	14 Nov 2025, 15:45

Holdings date	Option	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025			-3.7%	$0	0	-3,447,156	-100%	$22.05	Q4 2025
30 Sep 2025		3.7%	-9.2%	$78,009,140	3,447,156	-8,448,652	-71%	$22.63	Q3 2025
30 Jun 2025		12%	0%	$205,916,436	11,895,808	0		$17.31	Q2 2025
31 Mar 2025		15%	+0.01%	$260,161,321	11,895,808	+4,965		$21.87	Q1 2025
31 Dec 2024		15%	0%	$379,436,800	11,890,843	0		$31.91	Q4 2024
30 Sep 2024		12%	+0.28%	$342,931,912	11,890,843	+283,418	+2.4%	$28.84	Q3 2024
30 Jun 2024		14%	+0.24%	$445,260,823	11,607,425	+250,000	+2.2%	$38.36	Q2 2024
31 Mar 2024		17%	+0.28%	$667,589,442	11,357,425	+184,357	+1.7%	$58.78	Q1 2024
31 Dec 2023		17%	+0.42%	$668,819,850	11,173,068	+273,209	+2.5%	$59.86	Q4 2023
31 Dec 2023	call		-97%	$0	0	-732,500	-100%	$22.05	Q4 2023
30 Sep 2023		14%	+7.1%	$414,630,636	10,899,859	+5,448,212	+100%	$38.04	Q3 2023
30 Sep 2023	call	97%	+97%	$27,864,300	732,500	+732,500	NEW	$38.04	Q3 2023
30 Jun 2023		13%	0%	$496,645,042	5,451,647	0		$91.10	Q2 2023
31 Mar 2023		12%	+0.57%	$359,590,636	5,451,647	+268,216	+5.2%	$65.96	Q1 2023
31 Dec 2022		8.2%	0%	$268,035,217	5,183,431	0		$51.71	Q4 2022
30 Sep 2022		10%	0%	$354,028,000	5,183,431	0		$68.30	Q3 2022
30 Jun 2022		8.2%	0%	$234,395,000	5,183,431	0		$45.22	Q2 2022
31 Mar 2022		8.3%	+1.8%	$263,370,000	5,183,431	+1,149,549	+28%	$50.81	Q1 2022
31 Dec 2021		6.1%	+6.1%	$190,722,000	4,033,882	+4,033,882	NEW	$47.28	Q4 2021
30 Jun 2018			-2.5%	$0	0	-1,056,348	-100%	$22.05	Q2 2018
31 Mar 2018		2.5%	-0.21%	$23,356,000	1,056,348	-88,210	-7.7%	$22.11	Q1 2018
31 Dec 2017		3.3%	+3.3%	$24,837,000	1,144,558	+1,144,558	NEW	$21.70	Q4 2017

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.