EcoR1 Capital, LLC

Q4 2025 13F Holdings Report, Stock Holdings

Notable people: Oleg Nodelman
Signature - Title: Oleg Nodelman - Manager
Location: San Francisco, CA
Holdings as of: 31 Dec 2025
Value $: $2,182,086,314
Num holdings: 28
Filing time: 17 Feb 2026, 11:53:55 UTC
Form type: 13F-HR
Description: All US holdings of this investor are reported in this report. Top holdings included ZYME, ANAB, JAZZ, CRNX, and CNTA.
Previous filing: Q3 2025 - 14 Nov 2025
SEC: View on sec.gov
Options Holdings: Showing stock holdings, see here for options holdings

Sym	Weight	Trade Impact	Company	Class	Share Change	Activity	Value Change $	Value $	* Price $	Shares	Principal

Filing 2025 Q4 compared to 2025 Q3 by default. Changes are calculated vs the previous SEC filing.

Compare Q4 2025 to

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.

Person Signing this Report on Behalf of Reporting Manager:

Name	Title	City, State	Date
Oleg Nodelman	Manager	San Francisco, California	11 Feb 2026