TWO SIGMA ADVISERS, LP

Holdings History for Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share (SPRO)

Symbol: SPRO on Nasdaq
Investment type: Equity / Common Stock, par value $0.001 per share

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025	0%	+0%	$504,678	216,600	+216,600	NEW	$2.33	Q4 2025
30 Sep 2022		-0%	$0	0	-176,157	-100%	$2.37	Q3 2022
30 Jun 2022	0%	+0%	$131,000	176,157	+159,757	+974%	$0.74	Q2 2022
31 Mar 2022	0%	+0%	$143,000	16,400	+16,400	NEW	$8.72	Q1 2022
30 Jun 2021		-0%	$0	0	-24,528	-100%	$2.37	Q2 2021
31 Mar 2021	0%	+0%	$361,000	24,528	+5,200	+27%	$14.72	Q1 2021
31 Dec 2020	0%	-0%	$375,000	19,328	-2,100	-9.8%	$19.40	Q4 2020
30 Sep 2020	0%	+0%	$239,000	21,428	+5,100	+31%	$11.15	Q3 2020
30 Jun 2020	0%	+0%	$221,000	16,328	+16,328	NEW	$13.54	Q2 2020

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.