Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share (SPRO)

Q: What does CUSIP 84833T103 represent in this 13F holders report?

CUSIP 84833T103 is the security identifier for SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share used to aggregate holder disclosures.

Q: How many institutions held SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share in Q3 2022?

61 institutional investors reported SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share for Q3 2022. Use the holders table for investor-level position and value details.

CUSIP: 84833T103

Q3 2022 13F Holders as of 30 Sep 2022

Security type / class: Equity / Common Stock, par value $0.001 per share
Total 13F shares: 19,852,133
Total 13F value: $39,711,772
Share change: -1,092,122
Put/Call ratio: 1184%
SEC-reported price per share: $2.00
Number of holders: 61
Value change: +$134,944
Number of buys: 23
Number of sells: 34
Shares outstanding: 55,705,828

Security key

84833T103

Report period

Q3 2022

Institutions

Top holders

SPRO full security history Ownership snapshot Full 13F holder table Newer quarter: Q4 2022 Previous quarter: Q2 2022 Spero Therapeutics, Inc. SEC filings Spero Therapeutics, Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 84833T103

Newer quarter: Q4 2022 Previous quarter: Q2 2022

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Ownership snapshot

Top reported holders of SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

Aquilo Capital Management...

Disclosed value leader

Aquilo Capital Management...

Comparable rows

15/15

Latest evidence

22 Sep 2022

3/4/5 13F Lead comparable stake: 9.6% Showing 1-6 of 15 holder rows.

Quick read

Aquilo Capital Management, LLC leads the comparable SEC ownership view at 9.6%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens Aquilo Capital Management, LLC's linked filing trail.

Comparable ownership Top 5

Aquilo Capital Management, LLC 9.6%

BVF INC/IL 5.5%

Atlas Venture Associates IX, LLC 2.5%

VANGUARD GROUP INC 2.2%

Atlas Venture Life Science Adviso... 1.9%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Aquilo Capital Management, LLC	3/4/5 13F 10%+ Owner · Company 3/4/5 13F	9.6% from 13F	$4,342,682 3,419,435 shares	—	22 Sep 2022
BVF INC/IL	13F Company 13F	5.5%	$2,289,000 3,089,615 shares	—	30 Jun 2022
Atlas Venture Associates IX, LLC	13F Company 13F	2.5%	$1,019,000 1,376,968 shares	—	30 Jun 2022
VANGUARD GROUP INC	13F Company 13F	2.2%	$924,000 1,245,992 shares	—	30 Jun 2022
Atlas Venture Life Science Advisors, LLC	13F Company 13F	1.9%	$764,000 1,031,160 shares	—	30 Jun 2022
RENAISSANCE TECHNOLOGIES LLC	13F Company 13F	1.7%	$696,000 939,017 shares	—	30 Jun 2022

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q3 2022

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

19,852,133

Rows available

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q3 2022 vs Q2 2022 Across Filers

Q2 2022 holders

Q3 2022 holders

Holder diff

Investor	Q2 2022 Shares	Q3 2022 Shares	Share Diff	Share Chg %	Q2 2022 value	Q3 2022 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend