BAKER BROS. ADVISORS LP

Holdings History for Xenon Pharmaceuticals Inc. - Common Stock (XENE)

Symbol: XENE on Nasdaq
Investment type: Equity / Common Stock

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025	0.1%	0%	$16,592,723	370,208	0		$44.82	Q4 2025
30 Sep 2025	0.11%	0%	$14,863,851	370,208	0		$40.15	Q3 2025
30 Jun 2025	0.11%	+0.01%	$11,587,510	370,208	+22,800	+6.6%	$31.30	Q2 2025
31 Mar 2025	0.13%	-0.24%	$11,655,538	347,408	-646,271		$33.55	Q1 2025
31 Dec 2024	0.42%	0%	$38,952,217	993,679	0		$39.20	Q4 2024
30 Sep 2024	0.41%	0%	$39,121,142	993,679	0		$39.37	Q3 2024
30 Jun 2024	0.5%	0%	$38,743,544	993,679	0		$38.99	Q2 2024
31 Mar 2024	0.54%	0%	$42,777,881	993,679	0		$43.05	Q1 2024
31 Dec 2023	0.52%	+0.13%	$45,768,855	993,679	+242,040	+32%	$46.06	Q4 2023
30 Sep 2023	0.15%	0%	$25,675,988	751,639	0		$34.16	Q3 2023
30 Jun 2023	0.17%	0%	$28,938,102	751,639	0		$38.50	Q2 2023
31 Mar 2023	0.15%	0%	$26,901,160	751,639	0		$35.79	Q1 2023
31 Dec 2022	0.18%	0%	$29,637,126	751,639	0		$39.43	Q4 2022
30 Sep 2022	0.18%	0%	$27,134,000	751,639	0		$36.10	Q3 2022
30 Jun 2022	0.13%	0%	$22,865,000	751,639	0		$30.42	Q2 2022
31 Mar 2022	0.13%	0%	$22,978,000	751,639	0		$30.57	Q1 2022
31 Dec 2021	0.11%	0%	$23,481,000	751,639	0		$31.24	Q4 2021
30 Sep 2021	0.05%	0%	$11,485,000	751,639	0		$15.28	Q3 2021
30 Jun 2021	0.06%	0%	$13,996,000	751,639	0		$18.62	Q2 2021
31 Mar 2021	0.06%	+0%	$13,454,000	751,639	+64,253	+9.3%	$17.90	Q1 2021
31 Dec 2020	0.04%	-0%	$10,572,000	687,386	-72,922	-9.6%	$15.38	Q4 2020
30 Sep 2020	0.03%	-0%	$8,417,000	760,308	-38,794	-4.9%	$11.07	Q3 2020
30 Jun 2020	0.04%	+0.04%	$10,021,000	799,102	+799,102	NEW	$12.54	Q2 2020

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.