BAKER BROS. ADVISORS LP

Holdings History for AGIOS PHARMACEUTICALS, INC. - Common stock, par value $0.0001 per share (AGIO)

Symbol: AGIO on Nasdaq
Investment type: Equity / Common stock, par value $0.0001 per share

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025		-0.06%	$0	0	-189,866	-100%	$27.56	Q4 2025
30 Sep 2025	0.06%	0%	$7,621,221	189,866	0		$40.14	Q3 2025
30 Jun 2025	0.06%	+0.06%	$6,314,943	189,866	+189,866	NEW	$33.26	Q2 2025
31 Mar 2018		-0.06%	$0	0	-128,666	-100%	$27.56	Q1 2018
31 Dec 2017	0.06%	0%	$7,356,000	128,666	0		$57.17	Q4 2017
30 Sep 2017	0.07%	0%	$8,588,000	128,666	0		$66.75	Q3 2017
30 Jun 2017	0.06%	0%	$6,620,000	128,666	0		$51.45	Q2 2017
31 Mar 2017	0.06%	0%	$7,514,000	128,666	0		$58.40	Q1 2017
31 Dec 2016	0.05%	-0.03%	$5,369,000	128,666	-79,249	-38%	$41.73	Q4 2016
30 Sep 2016	0.1%	0%	$10,982,000	207,915	0		$52.82	Q3 2016
30 Jun 2016	0.09%	-0.04%	$8,711,000	207,915	-100,000	-32%	$41.90	Q2 2016
31 Mar 2016	0.13%	+0.09%	$12,501,000	307,915	+207,915	+208%	$40.60	Q1 2016
31 Dec 2015	0.05%	0%	$6,492,000	100,000	0		$64.92	Q4 2015
30 Sep 2015	0.07%	0%	$7,059,000	100,000	0		$70.59	Q3 2015
30 Jun 2015	0.1%	-0.05%	$11,114,000	100,000	-49,954	-33%	$111.14	Q2 2015
31 Mar 2015	0.12%	-0.01%	$14,141,000	149,954	-13,439	-8.2%	$94.30	Q1 2015
31 Dec 2014	0.19%	-0.01%	$18,307,000	163,393	-6,500	-3.8%	$112.04	Q4 2014
30 Sep 2014	0.13%	-0.02%	$10,423,000	169,893	-30,000	-15%	$61.35	Q3 2014
30 Jun 2014	0.11%	0%	$9,159,000	199,893	0		$45.82	Q2 2014
31 Mar 2014	0.1%	-0%	$7,826,000	199,893	-5,857	-2.8%	$39.15	Q1 2014
31 Dec 2013	0.07%	0%	$4,928,000	205,750	0		$23.95	Q4 2013

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.