| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 9.8% | $354M | 6.06M | FMR LLC | Sep 30, 2025 | |||
| RTW INVESTMENTS, LP | 7.2% | -24.4% | $258M | -$42.8M | 4.42M | -14.2% | RTW Investments, LP | Sep 30, 2025 |
| EcoR1 Capital, LLC | 7.5% | $51.8M | 3.63M | EcoR1 Capital, LLC | Dec 10, 2024 | |||
| Avoro Capital Advisors LLC | 6.6% | $52.2M | 3.63M | Avoro Capital Advisors LLC | Jun 30, 2025 | |||
| Aberdeen Group plc | 4.77% | -5% | $172M | $11M | 2.94M | +6.87% | Aberdeen Group plc | Sep 30, 2025 |
| Nantahala Capital Management, LLC | 3.75% | -39.5% | $29.5M | -$13.4M | 2.05M | -31.2% | Nantahala Capital Management, LLC | Jun 30, 2025 |
| Vestal Point Capital, LP | 0.4% | -91.4% | $13.1M | -$203M | 225K | -93.9% | Vestal Point Capital, LP | Sep 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 55.4M | $3.23B | +$238M | $58.37 | 218 |
| 2025 Q2 | 53M | $738M | +$50.6M | $13.94 | 143 |
| 2025 Q1 | 50M | $532M | +$84.8M | $10.60 | 139 |
| 2024 Q4 | 41.6M | $734M | +$59.6M | $17.66 | 136 |
| 2024 Q3 | 38.9M | $193M | +$40.2M | $4.93 | 129 |
| 2024 Q2 | 31.7M | $142M | -$2.9M | $4.48 | 114 |
| 2024 Q1 | 32.1M | $167M | -$35.8M | $5.20 | 129 |
| 2023 Q4 | 37.5M | $254M | -$6.87M | $6.77 | 144 |
| 2023 Q3 | 35.4M | $237M | -$15.3M | $6.71 | 160 |
| 2023 Q2 | 35.7M | $409M | -$103M | $11.46 | 175 |
| 2023 Q1 | 41.4M | $833M | +$27.8M | $20.14 | 170 |
| 2022 Q4 | 40M | $907M | -$33.4M | $22.67 | 173 |
| 2022 Q3 | 41.9M | $785M | +$15.1M | $18.76 | 154 |
| 2022 Q2 | 40.3M | $752M | +$52.2M | $18.64 | 162 |
| 2022 Q1 | 37.8M | $683M | +$3.74M | $18.07 | 162 |
| 2021 Q4 | 37.5M | $779M | -$10.6M | $20.74 | 170 |
| 2021 Q3 | 36.9M | $1.18B | +$36.6M | $32.01 | 169 |
| 2021 Q2 | 35.8M | $1.1B | -$14.7M | $30.80 | 152 |
| 2021 Q1 | 36.2M | $1.22B | +$31.6M | $33.69 | 152 |
| 2020 Q4 | 35M | $1.26B | -$11.7M | $36.13 | 160 |
| 2020 Q3 | 35.3M | $1.3B | -$827K | $36.83 | 160 |
| 2020 Q2 | 35M | $1.57B | -$20.3M | $45.06 | 172 |
| 2020 Q1 | 35.3M | $1.68B | -$22.5M | $47.45 | 170 |
| 2019 Q4 | 34.7M | $2.48B | +$184M | $71.66 | 181 |
| 2019 Q3 | 32M | $1.26B | +$155M | $39.36 | 156 |
| 2019 Q2 | 26.4M | $2.07B | +$441M | $78.15 | 148 |
| 2019 Q1 | 22.7M | $1.35B | +$7.09M | $59.65 | 130 |
| 2018 Q4 | 22.8M | $656M | -$4.28M | $28.82 | 94 |
| 2018 Q3 | 22.6M | $822M | +$5.79M | $36.39 | 99 |
| 2018 Q2 | 22M | $833M | +$220M | $37.80 | 94 |
| 2018 Q1 | 16.3M | $382M | +$66.9M | $23.50 | 66 |
| 2017 Q4 | 13.5M | $265M | +$106M | $19.59 | 60 |
| 2017 Q3 | 7.67M | $73.6M | +$259K | $9.60 | 35 |
| 2017 Q2 | 7.65M | $47.4M | +$3.03M | $6.19 | 31 |
| 2017 Q1 | 7.21M | $41.7M | -$1.97M | $5.78 | 37 |
| 2016 Q4 | 7.62M | $42.7M | -$3.17M | $5.60 | 50 |
| 2016 Q3 | 7.08M | $54.1M | -$8.02M | $7.65 | 48 |
| 2016 Q2 | 8.14M | $60M | -$8.78M | $7.37 | 57 |
| 2016 Q1 | 9.14M | $109M | +$7.83M | $11.88 | 56 |
| 2015 Q4 | 8.22M | $136M | -$885K | $16.54 | 64 |
| 2015 Q3 | 7.93M | $162M | -$249K | $20.45 | 62 |
| 2015 Q2 | 7.68M | $207M | +$75.4M | $27.00 | 53 |
| 2015 Q1 | 4.92M | $120M | +$30.9M | $24.32 | 40 |
| 2014 Q4 | 3.8M | $56.3M | +$6.55M | $14.81 | 26 |
| 2014 Q3 | 3.46M | $31.9M | -$65.7K | $9.24 | 26 |
| 2014 Q2 | 3.42M | $46.5M | +$44.4K | $13.59 | 26 |
| 2014 Q1 | 3.34M | $52M | +$52M | $15.55 | 24 |