| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Qiming Venture Partners IV, L.P. | 5.97% | $2,365,303,551 | 66,329,320 | Qiming Corporate GP IV, Ltd. | 30 Jun 2025 | |||
| RTW INVESTMENTS, LP | 2.1% | -60% | $776,545,971 | -$1,099,901,306 | 22,913,720 | -58.6% | RTW Investments, LP | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 35,163,819 | $1,191,548,050 | -$254,812,706 | $33.89 | 137 |
| 2025 Q2 | 42,596,490 | $1,489,575,949 | -$413,866,563 | $34.97 | 153 |
| 2025 Q1 | 54,354,713 | $1,968,916,000 | -$65,840,101 | $36.14 | 158 |
| 2024 Q4 | 56,344,833 | $1,475,697,182 | +$282,698,047 | $26.19 | 129 |
| 2024 Q3 | 45,281,591 | $1,092,880,285 | +$127,670,248 | $24.14 | 102 |
| 2024 Q2 | 40,522,673 | $702,153,167 | +$18,622,237 | $17.33 | 103 |
| 2024 Q1 | 41,147,009 | $659,065,362 | -$18,706,265 | $16.02 | 115 |
| 2023 Q4 | 41,015,622 | $1,120,873,222 | +$48,948,854 | $27.33 | 120 |
| 2023 Q3 | 39,262,224 | $954,099,816 | -$90,395,051 | $24.31 | 119 |
| 2023 Q2 | 42,648,412 | $1,185,016,441 | -$306,108,893 | $27.73 | 135 |
| 2023 Q1 | 52,888,961 | $1,759,064,052 | -$156,225,112 | $33.26 | 158 |
| 2022 Q4 | 57,708,310 | $1,771,980,125 | -$40,130,592 | $30.7 | 161 |
| 2022 Q3 | 59,078,776 | $2,020,875,363 | -$45,377,506 | $34.2 | 163 |
| 2022 Q2 | 60,363,203 | $2,092,993,511 | -$58,996,559 | $34.68 | 154 |
| 2022 Q1 | 61,534,638 | $2,705,973,136 | -$205,164,959 | $43.98 | 166 |
| 2021 Q4 | 64,537,843 | $4,057,860,045 | -$74,113,683 | $62.85 | 197 |
| 2021 Q3 | 64,063,848 | $6,752,343,102 | +$155,334,361 | $105.39 | 219 |
| 2021 Q2 | 61,361,677 | $10,854,273,878 | +$1,384,583,611 | $176.99 | 228 |
| 2021 Q1 | 54,242,481 | $7,235,875,607 | +$118,680,137 | $133.43 | 216 |
| 2020 Q4 | 52,143,835 | $7,056,266,230 | +$525,905,376 | $135.34 | 184 |
| 2020 Q3 | 50,066,541 | $4,159,868,941 | +$164,807,578 | $83.17 | 173 |
| 2020 Q2 | 48,007,738 | $3,939,583,811 | +$167,669,947 | $82.13 | 167 |
| 2020 Q1 | 46,171,446 | $2,377,201,339 | +$453,931,003 | $51.48 | 132 |
| 2019 Q4 | 37,380,146 | $1,555,042,457 | -$10,447,450 | $41.59 | 100 |
| 2019 Q3 | 37,091,034 | $1,200,869,356 | +$64,742,057 | $32.35 | 88 |
| 2019 Q2 | 35,074,938 | $1,222,723,384 | +$486,970,041 | $34.87 | 80 |
| 2019 Q1 | 21,208,398 | $625,651,000 | +$5,950,313 | $29.51 | 68 |
| 2018 Q4 | 21,020,627 | $487,979,000 | +$9,022,608 | $23.22 | 60 |
| 2018 Q3 | 20,231,258 | $394,105,000 | +$153,220,165 | $19.48 | 60 |
| 2018 Q2 | 12,321,983 | $286,484,000 | +$34,539,314 | $23.25 | 38 |
| 2018 Q1 | 10,842,196 | $231,479,000 | +$10,475,120 | $21.35 | 35 |
| 2017 Q4 | 10,354,516 | $219,827,000 | +$19,200,370 | $21.23 | 33 |
| 2017 Q3 | 9,154,332 | $247,165,000 | +$245,612,000 | $27 | 47 |