| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 0% | -103% | $1,250 | -$367,360 | 3,732 | -100% | Kenneth Griffin | 30 Sep 2025 |
As of 30 Sep 2025, 31 institutional investors reported holding 3,924,005 shares of VYNE Therapeutics Inc. - Common Stock, par value $0.0001 per share (VYNE). This represents 21% of the company’s total 18,514,484 outstanding shares.
The largest institutional shareholders of VYNE Therapeutics Inc. - Common Stock, par value $0.0001 per share (VYNE) together control 21% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4.6% | 851,353 | 0% | $285,203 | |
| ACORN CAPITAL ADVISORS, LLC | 3.2% | 586,572 | -20% | 0.1% | $199,434 |
| Shay Capital LLC | 2.7% | 492,577 | 0.03% | $165,013 | |
| ACADIAN ASSET MANAGEMENT LLC | 2.4% | 446,414 | +1891% | 0% | $148,000 |
| Ikarian Capital, LLC | 1.6% | 290,000 | 0% | 0.02% | $97,149 |
| TWO SIGMA INVESTMENTS, LP | 1.2% | 220,788 | 0% | $73,964 | |
| VANGUARD GROUP INC | 1% | 190,383 | -62% | 0% | $63,778 |
| JANE STREET GROUP, LLC | 0.79% | 147,120 | +18% | 0% | $49,285 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.74% | 137,122 | +2.8% | 0% | $45,938 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.58% | 106,459 | 0% | 0% | $35,664 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.42% | 76,958 | 0% | 0% | $25,781 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.31% | 57,763 | -0.09% | 0% | $19,351 |
| TWO SIGMA ADVISERS, LP | 0.31% | 56,600 | 0% | $18,961 | |
| Rangeley Capital, LLC | 0.27% | 50,000 | 0.02% | $16,750 | |
| CORSAIR CAPITAL MANAGEMENT, L.P. | 0.27% | 50,000 | +400% | 0% | $16,750 |
| BlackRock, Inc. | 0.24% | 44,404 | -0% | 0% | $14,875 |
| GSA CAPITAL PARTNERS LLP | 0.19% | 35,921 | +167% | 0% | $12,000 |
| NORTHERN TRUST CORP | 0.12% | 23,110 | 0% | 0% | $7,742 |
| COMMONWEALTH EQUITY SERVICES, LLC | 0.1% | 18,298 | 0% | 0% | $6,000 |
| STATE STREET CORP | 0.09% | 15,765 | 0% | 0% | $5,281 |
| Harvest Investment Services, LLC | 0.06% | 11,059 | -78% | 0% | $3,705 |
| UBS Group AG | 0.03% | 5,572 | 0% | $1,866 | |
| Tower Research Capital LLC (TRC) | 0.02% | 3,597 | +28% | 0% | $1,205 |
| ROYAL BANK OF CANADA | 0.01% | 2,440 | 0% | 0% | $1,000 |
| BANK OF AMERICA CORP /DE/ | 0.01% | 1,532 | +4.3% | 0% | $513 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 26,051 | $14,610 | +$14,000 | $0.58 | 3 |
| 2025 Q3 | 3,924,005 | $1,315,944 | -$9,032,746 | $0.34 | 31 |
| 2025 Q2 | 8,048,768 | $13,279,291 | +$1,503,898 | $1.65 | 44 |
| 2025 Q1 | 7,109,939 | $11,401,092 | -$2,382,241 | $1.58 | 36 |
| 2024 Q4 | 7,028,274 | $23,320,995 | +$606,162 | $3.35 | 34 |
| 2024 Q3 | 7,312,555 | $14,256,902 | -$1,226,342 | $1.88 | 31 |
| 2024 Q2 | 7,942,286 | $16,030,293 | +$243,077 | $1.97 | 30 |
| 2024 Q1 | 6,405,086 | $19,663,149 | +$378,435 | $3.07 | 29 |
| 2023 Q4 | 7,863,834 | $18,322,345 | +$17,207,859 | $2.33 | 32 |
| 2023 Q3 | 360,099 | $1,445,870 | -$33,734 | $4.04 | 20 |
| 2023 Q2 | 375,960 | $1,532,386 | +$198,131 | $4.10 | 19 |
| 2023 Q1 | 335,259 | $1,031,948 | +$1,031,948 | $3.08 | 19 |