Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA)

Q: What does CUSIP 90240B106 represent in this 13F holders report?

CUSIP 90240B106 is the security identifier for TYRA - Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") used to aggregate holder disclosures.

Q: How many institutions held TYRA - Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") in Q4 2025?

133 institutional investors reported TYRA - Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") for Q4 2025. Use the holders table for investor-level position and value details.

CUSIP: 90240B106

Q4 2025 13F Holders as of 31 Dec 2025

Type / Class: Equity / Common Stock, $0.0001 par value per share (the "Shares")
Shares outstanding: 54,254,818
Total 13F shares: 56,830,609
Share change: +133,090
Total reported value: $1,493,991,866
Price per share: $26.29
Number of holders: 133
Value change: +$12,760,989
Number of buys: 67
Number of sells: 47

Quarterly Holders Quick Answers

What is CUSIP 90240B106?
CUSIP 90240B106 identifies TYRA - Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") in SEC institutional holdings data.

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Explore More Reporting Periods

Jump to adjacent filing periods for faster comparison and easier crawl discovery.

Newer quarter: Q1 2026
Previous quarter: Q3 2025

Recent filing periods for CUSIP 90240B106:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Top shareholders of TYRA - Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
RA CAPITAL MANAGEMENT, L.P.	13F 3/4/5	Company · Director, 10%+ Owner	22%	12,198,625	$170,658,764	—	30 Sep 2025	13F 3/4/5
Boxer Capital Management, LLC	3/4/5	Other*	— mixed-class rows	7,153,639 mixed-class rows	$125,264,455	—	18 Oct 2024	3/4/5
Nina S. Kjellson	3/4/5	Director	— mixed-class rows	7,975,964 mixed-class rows	$122,459,032	—	05 Feb 2025	3/4/5
Robert J. More	3/4/5	Director	— mixed-class rows	3,845,625 mixed-class rows	$95,585,625	-$5,250,026	19 Dec 2025	3/4/5
Boxer Capital, LLC	3/4/5	Other*	— mixed-class rows	7,239,578 mixed-class rows	$94,186,205	—	06 Feb 2024	3/4/5
Todd Harris	13D/G	—	5.1%	2,814,379	$85,416,403	$0	31 Dec 2025	13D/G
BIOTECHNOLOGY VALUE FUND L P	13D/G	BVF PARTNERS L P/IL	4%	2,127,665	$64,574,633	-$55,131,655	31 Dec 2025	13D/G
Alta Partners Management Company, L.P.	13F	Company	7.5%	4,080,296	$57,083,341	—	30 Sep 2025	13F
Nextech Invest, Ltd.	13F	Company	7.5%	4,055,861	$56,741,495	—	30 Sep 2025	13F
BVF INC/IL	13F	Company	6.7%	3,649,794	$51,060,618	—	30 Sep 2025	13F
Canaan Partners XI LLC	13F	Company	6.7%	3,608,109	$50,477,445	—	30 Sep 2025	13F
Commodore Capital LP	13D/G 13F	Company	6.3%	3,375,000	$47,216,250	+$8,743,750	30 Sep 2025	13D/G 13F
TCG Crossover Management, LLC	13F	Company	5.3%	2,898,103	$40,544,461	—	30 Sep 2025	13F
JANUS HENDERSON GROUP PLC	13F 13D/G	Company	5.4% from 13D/G	2,874,804	$40,232,882	—	30 Sep 2025	13F 13D/G
Vestal Point Capital, LP	13D/G 13F	Company	4.5%	2,425,000	$33,925,750	-$6,363,058	30 Sep 2025	13D/G 13F
Kynam Capital Management, LP	13F	Company	4.3%	2,329,998	$32,596,672	—	30 Sep 2025	13F
TCG Crossover GP I, LLC	13D/G	—	5.7%	2,898,103	$29,792,499	$0	27 Feb 2025	13D/G
Alta Partners NextGen Fund II Management, LLC	3/4/5	10%+ Owner	— class O/S missing	4,080,296	$26,844,267	—	17 Sep 2021	3/4/5
BlackRock, Inc.	13F	Company	3.4%	1,869,474	$26,153,941	—	30 Sep 2025	13F
VANGUARD GROUP INC	13F	Company	2.8%	1,520,185	$21,267,388	—	30 Sep 2025	13F
FARALLON CAPITAL MANAGEMENT LLC	13F	Company	2.1%	1,143,818	$16,002,014	—	30 Sep 2025	13F
5AM Venture Management, LLC	13F	Company	1.7%	939,298	$13,140,779	—	30 Sep 2025	13F
BALYASNY ASSET MANAGEMENT L.P.	13F	Company	1.6%	846,585	$11,843,724	—	30 Sep 2025	13F
Caligan Partners LP	13F	Company	1.3%	696,825	$9,748,582	—	30 Sep 2025	13F
MARSHALL WACE, LLP	13F	Company	1.1%	602,015	$8,422,190	—	30 Sep 2025	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	1.1%	597,454	$8,359,761	—	30 Sep 2025	13F
Sio Capital Management, LLC	13F	Company	0.95%	514,947	$7,204,109	—	30 Sep 2025	13F
Cormorant Asset Management, LP	3/4/5	Former 10% Owner	— class O/S missing	1,069,932	$7,039,083	—	17 Sep 2021	3/4/5
STATE STREET CORP	13F	Company	0.79%	428,472	$5,994,323	—	30 Sep 2025	13F
MORGAN STANLEY	13F	Company	0.59%	322,143	$4,506,781	—	30 Sep 2025	13F
Walleye Capital LLC	13F	Company	0.55%	297,808	$4,166,334	—	30 Sep 2025	13F
Point72 Asset Management, L.P.	13F	Company	0.52%	282,032	$3,945,629	—	30 Sep 2025	13F
Eversept Partners, LP	13F	Company	0.5%	272,706	$3,815,157	—	30 Sep 2025	13F
JACOBS LEVY EQUITY MANAGEMENT, INC	13F	Company	0.46%	251,562	$3,519,352	—	30 Sep 2025	13F
Canaan XI L.P.	3/4/5	10%+ Owner	— class O/S missing	473,396	$3,114,472	—	17 Sep 2021	3/4/5
NORTHERN TRUST CORP	13F	Company	0.38%	208,486	$2,916,719	—	30 Sep 2025	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	0.37%	201,587	$2,820,202	—	30 Sep 2025	13F
TWO SIGMA INVESTMENTS, LP	13F	Company	0.37%	199,438	$2,790,138	—	30 Sep 2025	13F
BOOTHBAY FUND MANAGEMENT, LLC	13F	Company	0.34%	186,670	$2,611,513	—	30 Sep 2025	13F
RENAISSANCE TECHNOLOGIES LLC	13F	Company	0.31%	170,100	$2,379,699	—	30 Sep 2025	13F
MILLENNIUM MANAGEMENT LLC	13F	Company	0.27%	144,016	$2,014,784	—	30 Sep 2025	13F
BANK OF AMERICA CORP /DE/	13F	Company	0.25%	134,319	$1,879,123	—	30 Sep 2025	13F
BNP PARIBAS FINANCIAL MARKETS	13F	Company	0.24%	128,881	$1,803,045	—	30 Sep 2025	13F
AXA Investment Managers S.A.	13F	Company	0.24%	128,789	$1,801,758	—	30 Sep 2025	13F
Robert L. Hudkins	3/4/5	Chief Technology Officer	— class O/S missing	273,576	$1,799,857	—	15 Sep 2022	3/4/5
Ronald Swanson V	3/4/5	Chief Scientific Officer	— mixed-class rows	378,254 mixed-class rows	$1,797,738	—	06 Sep 2022	3/4/5
RAYMOND JAMES FINANCIAL INC	13F	Company	0.23%	126,374	$1,767,972	—	30 Sep 2025	13F
TWO SIGMA ADVISERS, LP	13F	Company	0.21%	113,200	$1,583,668	—	30 Sep 2025	13F
Esther van den Boom	3/4/5	Chief Financial Officer	— class O/S missing	240,542	$1,582,525	—	15 Sep 2022	3/4/5
CITADEL ADVISORS LLC	13F	Company	0.21%	111,293	$1,556,989	—	30 Sep 2025	13F

Institutional Holders of Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA) as of Q4 2025

As of 31 Dec 2025, Tyra Biosciences, Inc. - Common Stock, $0.0001 par value per share (the "Shares") (TYRA) was held by 133 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 56,830,609 shares. The largest 10 holders included RA CAPITAL MANAGEMENT, L.P., Nextech Invest, Ltd., Alta Partners Management Company, L.P., Commodore Capital LP, Canaan Partners XI LLC, JANUS HENDERSON GROUP PLC, TCG Crossover Management, LLC, Vestal Point Capital, LP, BVF INC/IL, and BlackRock, Inc.. This page lists 133 institutional shareholders reporting positions in this security for the Q4 2025 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q4 2025 vs Q3 2025 Across Filers

Q3 2025 holders

115

Q4 2025 holders

133

Holder diff

Investor	Q3 2025 Shares	Q4 2025 Shares	Share Diff	Share Chg %	Q3 2025 Value $	Q4 2025 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.