| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FARALLON PARTNERS L L C/CA | 10% | $119,266,365 | 13,461,215 | Dapice Joshua J. | 31 Dec 2025 | |||
| Farallon Capital Partners, L.P. | 9.7% | +16% | $90,358,800 | +$13,440,000 | 10,757,000 | +17% | Dapice Joshua J. | 30 Sep 2025 |
| EcoR1 Capital, LLC | 9.9% | $15,520,875 | 10,630,736 | EcoR1 Capital, LLC | 31 Dec 2024 | |||
| Adage Capital Management, L.P. | 7.9% | +281% | $124,643,107 | +$95,138,857 | 10,607,924 | +322% | Adage Capital Management, L.P. | 31 Dec 2025 |
| TCG Crossover GP II, LLC | 6.3% | $71,704,046 | 8,536,196 | TCG Crossover GP II, LLC | 30 Sep 2025 | |||
| BlackRock, Inc. | 6.3% | +26% | $75,107,682 | +$26,758,396 | 8,477,165 | +55% | BlackRock, Inc. | 31 Dec 2025 |
| Invus Global Management, LLC | 6.1% | +16% | $95,943,144 | +$26,815,686 | 8,165,374 | +39% | Raymond Debbane | 31 Dec 2025 |
| VANGUARD GROUP INC | 5% | $59,813,656 | 6,750,977 | The Vanguard Group | 31 Dec 2025 | |||
| Third Rock Ventures IV, L.P. | 4.7% | -18% | $74,901,244 | -$17,625,000 | 6,374,574 | -19% | Third Rock Ventures IV, L.P. | 06 Feb 2026 |
| Woodline Partners LP | 5.6% | $35,757,343 | 6,029,906 | Woodline Partners LP | 30 Jun 2025 | |||
| FMR LLC | 0% | $19,552 | 13,392 | FMR LLC | 29 Nov 2024 |
As of 31 Dec 2025, 102 institutional investors reported holding 65,776,312 shares of Tango Therapeutics, Inc. - Common Stock, $0.001 par value per share (TNGX). This represents 49% of the company’s total 133,858,590 outstanding shares.
The largest institutional shareholders of Tango Therapeutics, Inc. - Common Stock, $0.001 par value per share (TNGX) together control 47% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 6.4% | 8,540,797 | +51% | 0% | $75,671,463 |
| Siren, L.L.C. | 6.1% | 8,165,374 | +39% | 2.2% | $72,345,214 |
| TRV GP IV, LLC | 5.9% | 7,874,574 | -43% | 27% | $69,768,726 |
| VANGUARD GROUP INC | 5% | 6,750,977 | +34% | 0% | $59,813,655 |
| STATE STREET CORP | 4.6% | 6,218,567 | +85% | 0% | $55,096,504 |
| GOLDMAN SACHS GROUP INC | 3.7% | 4,942,414 | +227% | 0.01% | $43,789,788 |
| Nantahala Capital Management, LLC | 2.7% | 3,572,633 | +97% | 1.9% | $31,653,528 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 2,553,656 | +36% | 0% | $22,629,824 |
| Deep Track Capital, LP | 1.8% | 2,454,562 | +69% | 0.5% | $21,747,419 |
| Vivo Capital, LLC | 1.6% | 2,154,780 | +177% | 1.2% | $19,091,351 |
| MORGAN STANLEY | 1.1% | 1,421,794 | +465% | 0% | $12,597,094 |
| FRANKLIN RESOURCES INC | 1% | 1,398,057 | +51% | 0% | $12,386,785 |
| Affinity Asset Advisors, LLC | 0.75% | 1,000,000 | 0.64% | $8,860,000 | |
| UBS Group AG | 0.74% | 990,458 | +517% | 0% | $8,775,458 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.63% | 840,992 | +28% | 0% | $7,451,189 |
| Candriam S.C.A. | 0.53% | 708,812 | 0% | 0.03% | $6,280,342 |
| BESSEMER GROUP INC | 0.53% | 708,398 | 0% | 0.01% | $6,276,000 |
| DIMENSIONAL FUND ADVISORS LP | 0.36% | 487,076 | -28% | 0% | $4,315,493 |
| BARCLAYS PLC | 0.28% | 368,187 | +0.69% | 0% | $3,262,136 |
| Mass General Brigham, Inc | 0.26% | 354,192 | 0% | 0.39% | $3,138,141 |
| Bank of New York Mellon Corp | 0.26% | 343,840 | +79% | 0% | $3,046,426 |
| MARSHALL WACE, LLP | 0.25% | 329,231 | -78% | 0% | $2,916,987 |
| Nuveen, LLC | 0.22% | 300,441 | -68% | 0% | $2,661,907 |
| GREAT LAKES ADVISORS, LLC | 0.22% | 294,303 | -31% | 0.02% | $2,607,525 |
| CONGRESS ASSET MANAGEMENT CO | 0.18% | 234,628 | +2.9% | 0.01% | $2,078,804 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 65,776,312 | $582,697,841 | +$87,647,602 | $8.86 | 102 |
| 2025 Q3 | 139,978,941 | $1,175,803,271 | +$109,407,056 | $8.40 | 141 |
| 2025 Q2 | 127,196,008 | $651,244,300 | +$113,427,538 | $5.12 | 114 |
| 2025 Q1 | 107,228,944 | $146,966,295 | -$1,500,604 | $1.37 | 119 |
| 2024 Q4 | 106,381,203 | $328,721,243 | -$120,601,739 | $3.09 | 134 |
| 2024 Q3 | 101,459,260 | $781,203,088 | -$3,564,439 | $7.70 | 119 |
| 2024 Q2 | 98,595,824 | $845,901,469 | +$2,628,498 | $8.58 | 116 |
| 2024 Q1 | 98,377,909 | $781,109,580 | +$30,778,538 | $7.94 | 124 |
| 2023 Q4 | 93,643,916 | $927,104,831 | +$41,143,001 | $9.90 | 118 |
| 2023 Q3 | 88,799,639 | $999,861,944 | +$236,872,193 | $11.26 | 99 |
| 2023 Q2 | 68,320,832 | $226,845,382 | -$7,737,842 | $3.32 | 89 |
| 2023 Q1 | 69,836,747 | $275,851,159 | +$1,770,332 | $3.95 | 91 |
| 2022 Q4 | 68,766,073 | $498,554,976 | +$12,927,727 | $7.25 | 83 |
| 2022 Q3 | 68,157,717 | $246,729,459 | -$12,119,590 | $3.62 | 86 |
| 2022 Q2 | 70,452,006 | $319,137,805 | -$11,072,751 | $4.53 | 76 |
| 2022 Q1 | 69,679,958 | $528,174,476 | +$13,385,662 | $7.58 | 70 |
| 2021 Q4 | 67,775,150 | $740,996,532 | +$24,899,642 | $10.94 | 57 |
| 2021 Q3 | 65,465,348 | $844,863,000 | +$844,863,000 | $12.93 | 45 |