Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") (SPRB)

Q: What does CUSIP 85209E109 represent in this 13F holders report?

CUSIP 85209E109 is the security identifier for SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") used to aggregate holder disclosures.

Q: How many institutions held SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") in Q1 2025?

30 institutional investors reported SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") for Q1 2025. Use the holders table for investor-level position and value details.

CUSIP: 85209E109

Q1 2025 13F Holders as of 31 Mar 2025

Security type / class: Equity / Common Stock, par value $0.0001 per share (the "Shares")
Total 13F shares: 10,436,798
Total 13F value: $3,024,802
Share change: -728,120
SEC-reported price per share: $0.29
Number of holders: 30
Value change: -$321,461
Number of buys: 10
Number of sells: 12
Shares outstanding: 1,373,824

Security key

85209E109

Report period

Q1 2025

Institutions

Top holders

SPRB full security history Ownership snapshot Full 13F holder table Newer quarter: Q3 2025 SPRUCE BIOSCIENCES, INC. SEC filings SPRUCE BIOSCIENCES, INC. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 85209E109

Newer quarter: Q3 2025

Recent filing periods:

Q3 2025

Ownership snapshot

Top reported holders of SPRB - Spruce Biosciences, Inc. - Common Stock, par value $0.0001 per share (the "Shares") (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

RiverVest Venture Fund II...

Disclosed value leader

Carlyle Group Inc.

Comparable rows

15/15

Latest evidence

07 Jan 2025

13D/G 13F Lead comparable stake: 4.2% 13D/G row: RiverVest Venture Fund III, L.P. Showing 1-6 of 15 holder rows.

Quick read

RiverVest Venture Fund III, L.P. leads the comparable SEC ownership view at 4.2%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens RiverVest Venture Fund III, L.P.'s linked filing trail.

Comparable ownership Top 5

RiverVest Venture Fund III, L.P. 4.2%

Carlyle Group Inc. 211%

Rock Springs Capital Management LP 190%

ACADIAN ASSET MANAGEMENT LLC 76%

Ikarian Capital, LLC 73%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
RiverVest Venture Fund III, L.P.	13D/G John P. McKearn, Ph.D. 13D/G	4.2%	$140,762 1,759,521 shares	$0	07 Jan 2025
Carlyle Group Inc.	13F Company 13F	211%	$1,216,538 2,896,518 shares	—	31 Dec 2024
Rock Springs Capital Management LP	13F Company 13F	190%	$1,095,833 2,609,125 shares	—	31 Dec 2024
ACADIAN ASSET MANAGEMENT LLC	13F Company 13F	76%	$437,000 1,045,828 shares	—	31 Dec 2024
Ikarian Capital, LLC	13F Company 13F	73%	$420,000 1,000,000 shares	—	31 Dec 2024
VANGUARD GROUP INC	13F Company 13F	61%	$354,415 843,844 shares	—	31 Dec 2024

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q1 2025

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

10,436,798

Rows available

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q1 2025 vs Q1 2025 Across Filers

Q1 2025 holders

Holder diff

Investor	Q1 2025 Shares	Q1 2025 Shares	Share Diff	Share Chg %	Q1 2025 value	Q1 2025 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend